Contents
Vol 3, Issue 66
Contents
Commentary
- “Creating Hope” and Other Incentives for Drug Development for Children
Proposed legislation would provide financial benefits for companies that develop drugs for treating rare pediatric diseases.
Perspective
- Leukotriene Inflammatory Mediators Meet Their Match
The main enzyme in the leukotriene biosynthesis pathway finally yields to crystallization, paving the way for new leukotriene-modifier drugs.
Research Articles
- Stromal Endothelial Cells Directly Influence Cancer Progression
Endothelial cells can serve as plastic paracrine regulators of cancer biology, modulating tumor growth and metastasis.
- An Aptamer-siRNA Chimera Suppresses HIV-1 Viral Loads and Protects from Helper CD4+ T Cell Decline in Humanized Mice
A dual-function aptamer that targets both a HIV-1 surface protein and a critical messenger RNA can inhibit HIV infection in humanized mice.
Editors' Choice
- Novel Peptide to Treat Sepsis-Induced Acute Lung Injury
Inhibition of protein kinase C-δ activity limits acute respiratory distress syndrome–related lung injury.
- Excited to Madness
Faltering inhibitory interneurons in the prefrontal cortex lead to chaos in the schizophrenia brain.
- Catastrophe in the Nucleus
Some cancers carry massive genomic rearrangements, confined to one chromosomal region, that are thought to arise in a single event.
Erratum
