Contents
Vol 3, Issue 65
Contents
Perspectives
- Targeting Pain Where It Resides … In the Brain
An adenylyl cyclase inhibitor blocks mechanical hypersensitivity in a mouse model of neuropathic pain without affecting cognitive or motor functions.
- Molecular Technologies Open New Clinical Genetic Vistas
New genome sequencing technologies show clinical potential for preconception carrier screening and noninvasive prenatal genetic diagnosis.
Research Articles
- Identification of an Adenylyl Cyclase Inhibitor for Treating Neuropathic and Inflammatory Pain
In animal models, an adenylyl cyclase 1 inhibitor acts as an effective treatment for neuropathic pain, in part by acting on the anterior cingulate cortex.
- Carrier Testing for Severe Childhood Recessive Diseases by Next-Generation Sequencing
Carrier testing for 448 severe childhood recessive diseases by next-generation sequencing has good predictive value and suggests that every individual carries about three disease mutations.
Editors' Choice
- Dad’s Diet and Baby’s Metabolism
Paternal diet affects lipid and cholesterol metabolism in the offspring.
- Pondering the Significance of PON1
Another strong pharmacogenetic variant for clopidogrel response emerges.
- A Fusion Protein Fix for Cuts and Scrapes
An engineered fusion protein speeds up healing of skin wounds in diabetic mice.
Podcast
- Science Translational Medicine Podcast: 12 January 2011
A conversation with Laird Jackson about using the latest genome sequencing technologies to develop new carrier and prenatal genetic tests.
Erratum
