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Research ArticleFragile X Syndrome
Epigenetic Modification of the FMR1 Gene in Fragile X Syndrome Is Associated with Differential Response to the mGluR5 Antagonist AFQ056
- Sébastien Jacquemont1,*,
- Aurore Curie2,*,
- Vincent des Portes2,
- Maria Giulia Torrioli3,
- Elizabeth Berry-Kravis4,
- Randi J. Hagerman5,
- Feliciano J. Ramos6,
- Kim Cornish7,
- Yunsheng He8,
- Charles Paulding8,
- Giovanni Neri9,
- Fei Chen1,10,
- Nouchine Hadjikhani10,11,
- Danielle Martinet1,
- Joanne Meyer8,
- Jacques S. Beckmann1,
- Karine Delange2,
- Amandine Brun2,
- Gerald Bussy2,
- Fabrizio Gasparini12,
- Talita Hilse13,
- Annette Floesser13,
- Janice Branson12,
- Graeme Bilbe12,
- Donald Johns14 and
- Baltazar Gomez-Mancilla14,†
- 1Service de Génétique Médicale, Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland.
- 2National Reference Center for Fragile X and Other XLMR, Hospices Civils de Lyon, Université de Lyon and CNRS UMR 5230 (L2C2), F-69675 Bron, France.
- 3Università Cattolica del Sacro Cuore, Cattedra di Neuropsichiatria Infantile, 00168 Rome, Italy.
- 4Departments of Pediatrics, Neurological Sciences, and Biochemistry, Rush University Medical Center, Chicago, IL 60612, USA.
- 5Department of Pediatrics and Medical Investigation of Neurodevelopmental Disorders (M.I.N.D.) Institute, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA.
- 6Department of Pediatrics, University of Zaragoza Medical School, 50009 Zaragoza, Spain.
- 7Centre for Developmental Psychiatry and Psychology, School of Psychology and Psychiatry, Monash University, Melbourne, Victoria 3800, Australia.
- 8Biomarker Development, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
- 9Università Cattolica del Sacro Cuore, Istituto di Genetica Medica, 00191 Rome, Italy.
- 10Brain Mind Institute, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
- 11Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, MA 02129, USA.
- 12Neuroscience Discovery, Novartis Pharma AG, CH-4056 Basel, Switzerland.
- 13Neuroscience Clinical Sciences and Innovation, Novartis Institutes for Biomedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland.
- 14Neuroscience Translational Medicine, Novartis Institutes for Biomedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland.
- †To whom correspondence should be addressed. E-mail: baltazar.gomezmancilla{at}novartis.com
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Science Translational Medicine 05 Jan 2011:
Vol. 3, Issue 64, pp. 64ra1
DOI: 10.1126/scitranslmed.3001708
Vol. 3, Issue 64, pp. 64ra1
DOI: 10.1126/scitranslmed.3001708
Sébastien Jacquemont
Aurore Curie
Vincent des Portes
Maria Giulia Torrioli
Elizabeth Berry-Kravis
Randi J. Hagerman
Feliciano J. Ramos
Kim Cornish
Yunsheng He
Charles Paulding
Giovanni Neri
Fei Chen
Nouchine Hadjikhani
Danielle Martinet
Joanne Meyer
Jacques S. Beckmann
Karine Delange
Amandine Brun
Gerald Bussy
Fabrizio Gasparini
Talita Hilse
Annette Floesser
Janice Branson
Graeme Bilbe
Donald Johns
Baltazar Gomez-Mancilla
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