Research ArticleFragile X Syndrome

Epigenetic Modification of the FMR1 Gene in Fragile X Syndrome Is Associated with Differential Response to the mGluR5 Antagonist AFQ056

See allHide authors and affiliations

Science Translational Medicine  05 Jan 2011:
Vol. 3, Issue 64, pp. 64ra1
DOI: 10.1126/scitranslmed.3001708

Article Information

vol. 3 no. 64 64ra1

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication September 15, 2010
  • Accepted for publication December 10, 2010
  • .

Author Information

  1. Sébastien Jacquemont1,*,
  2. Aurore Curie2,*,
  3. Vincent des Portes2,
  4. Maria Giulia Torrioli3,
  5. Elizabeth Berry-Kravis4,
  6. Randi J. Hagerman5,
  7. Feliciano J. Ramos6,
  8. Kim Cornish7,
  9. Yunsheng He8,
  10. Charles Paulding8,
  11. Giovanni Neri9,
  12. Fei Chen1,10,
  13. Nouchine Hadjikhani10,11,
  14. Danielle Martinet1,
  15. Joanne Meyer8,
  16. Jacques S. Beckmann1,
  17. Karine Delange2,
  18. Amandine Brun2,
  19. Gerald Bussy2,
  20. Fabrizio Gasparini12,
  21. Talita Hilse13,
  22. Annette Floesser13,
  23. Janice Branson12,
  24. Graeme Bilbe12,
  25. Donald Johns14 and
  26. Baltazar Gomez-Mancilla14,
  1. 1Service de Génétique Médicale, Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland.
  2. 2National Reference Center for Fragile X and Other XLMR, Hospices Civils de Lyon, Université de Lyon and CNRS UMR 5230 (L2C2), F-69675 Bron, France.
  3. 3Università Cattolica del Sacro Cuore, Cattedra di Neuropsichiatria Infantile, 00168 Rome, Italy.
  4. 4Departments of Pediatrics, Neurological Sciences, and Biochemistry, Rush University Medical Center, Chicago, IL 60612, USA.
  5. 5Department of Pediatrics and Medical Investigation of Neurodevelopmental Disorders (M.I.N.D.) Institute, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA.
  6. 6Department of Pediatrics, University of Zaragoza Medical School, 50009 Zaragoza, Spain.
  7. 7Centre for Developmental Psychiatry and Psychology, School of Psychology and Psychiatry, Monash University, Melbourne, Victoria 3800, Australia.
  8. 8Biomarker Development, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  9. 9Università Cattolica del Sacro Cuore, Istituto di Genetica Medica, 00191 Rome, Italy.
  10. 10Brain Mind Institute, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
  11. 11Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, MA 02129, USA.
  12. 12Neuroscience Discovery, Novartis Pharma AG, CH-4056 Basel, Switzerland.
  13. 13Neuroscience Clinical Sciences and Innovation, Novartis Institutes for Biomedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland.
  14. 14Neuroscience Translational Medicine, Novartis Institutes for Biomedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland.
  1. To whom correspondence should be addressed. E-mail: baltazar.gomezmancilla{at}novartis.com

Altmetric

Article usage

Article usage: December 2010 to September 2019

AbstractFullPdf
Dec 2010100
Jan 20112622176311
Feb 201197288117
Mar 201182161121
Apr 20115902760
May 20115042845
Jun 20115712352
Jul 20116291557
Aug 20115401647
Sep 20115182559
Oct 20115381960
Nov 20115632063
Dec 20113771744
Jan 20124601549
Feb 20123651245
Mar 20124431745
Apr 20126062662
May 20123892853
Jun 20123511646
Jul 201212501732
Aug 20125381933
Sep 20122783034
Oct 20123794962
Nov 20123904952
Dec 20122851326
Jan 20133114244
Feb 20132453332
Mar 20132392222
Apr 20133713635
May 20133624153
Jun 20132963331
Jul 20132443432
Aug 20131901824
Sep 20132342726
Oct 20132794736
Nov 20131942430
Dec 20131661422
Jan 20142922325
Feb 20142623232
Mar 20142311920
Apr 20141821521
May 20141761516
Jun 20141521811
Jul 201411688
Aug 20141371715
Sep 20141351418
Oct 20141532416
Nov 20141422010
Dec 20142921310
Jan 20152574332
Feb 20151241118
Mar 20151662617
Apr 20151461318
May 20151011213
Jun 2015143511
Jul 2015112611
Aug 20156747
Sep 20156986
Oct 20157387
Nov 201591521
Dec 20157657
Jan 20162321321
Feb 20161481423
Mar 20161531015
Apr 2016128611
May 2016141817
Jun 20161891215
Jul 2016120610
Aug 2016103813
Sep 2016223410
Oct 2016142412
Nov 2016169910
Dec 201620485
Jan 201711848
Feb 2017158116
Mar 2017164610
Apr 2017144314
May 2017147813
Jun 201710061
Jul 201710766
Aug 201710178
Sep 2017174510
Oct 201711685
Nov 201712548
Dec 20178826
Jan 20189755
Feb 20181121612
Mar 20189467
Apr 2018114107
May 201811172
Jun 20188774
Jul 20188889
Aug 201895144
Sep 20186974
Oct 201870157
Nov 20181111912
Dec 20188196
Jan 201971147
Feb 2019721911
Mar 201957216
Apr 20194864
May 201983167
Jun 20193661
Jul 2019591715
Aug 20193286
Sep 20191995