05 January 2011
Vol 3, Issue 64

About The Cover

Cover image expansion

ONLINE COVER Drug Delivery by Micelle. As discussed in the Research Article by Murakami et al., this polymeric micelle is ingested by cancer cells where it trafficks to the endosomes and lysosomes near the cell nuclei. In this acidic environment, the micelle dissociates, releasing a platinum-containing drug (yellow spheres) in the vicinity of its target, nuclear DNA. The micelle's journey inside the cell can be tracked by dyes (boron dipyrromethane FL and TR) attached to either end of the copolymer chains. The green dye is always visible, but the red dye at the center of the micelle only appears when it becomes unquenched as the micelle dissociates in acidic conditions. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]