21 December 2011
Vol 3, Issue 114

About The Cover

Cover image expansion

ONLINE COVER Spreading Severe Disease. Shown is a mosquito taking a blood meal from a person infected with dengue virus. The cells that line the bug’s gut become infected with the virus, which eventually moves to the salivary glands. When the bug bites its next human victim, the dengue virus–containing saliva goes into the skin, binds to and enters white blood cells, and reproduces while being escorted by the cells to other parts of the body. Infection with one dengue virus serotype offers a person lifelong protection against that serotype and temporary immune protection from severe dengue disease caused by a different dengue virus serotype. But once this immune-protected period passes, the individual becomes at increased risk for more severe disease. In this issue of Science Translational Medicine, OhAinle et al. dissect the intricate interactions between dengue virus immunity and viral genetics that drive dengue disease outcomes in Nicaraguan populations. [CREDIT: B. STRAUCH/SCIENCE TRANSLATIONAL MEDICINE]