Contents
Vol 3, Issue 113
Contents
Commentary
- dbGaP Data Access Requests: A Call for Greater Transparency
Mandatory data sharing offers scientific advantages, but more transparency around data use is needed to assess health benefits that result from translational research.
Perspective
- Receptor Antibodies as Novel Therapeutics for Diabetes
Designer antibodies and ligands that mimic hormone activity can enhance tissue specificity and provide new approaches to treating diabetes and other metabolic diseases.
Research Articles
- An NKG2D-Mediated Human Lymphoid Stress Surveillance Response with High Interindividual Variation
Humans mount lymphocyte stress surveillance responses to MICA, but they are individually tuned to optimal bandwidths.
- Pathogenesis of Lethal Cardiac Arrhythmias in Mecp2 Mutant Mice: Implication for Therapy in Rett Syndrome
Lethal ventricular arrhythmias in a mouse model of Rett syndrome can be prevented by phenytoin, which blocks a persistent sodium current.
- Amelioration of Type 2 Diabetes by Antibody-Mediated Activation of Fibroblast Growth Factor Receptor 1
Antibody-mediated activation of fibroblast growth factor receptor 1 reverses the diabetic phenotype in mice, likely by affecting brown adipose tissues.
Editors' Choice
- Cushing’s Disease Escapes the Knife
The tyrosine kinase inhibitor gefitinib shows promise for treating Cushing’s disease.
- Room for Expansion
A new bioprocess design strategy guides the expansion and differentiation of human pluripotent stem cells.
- Vectored Immunoprophylaxis and HIV: The New VIP on the Block
An adeno-associated virus expressing a human HIV-neutralizing antibody protects mice from HIV infection.
- Learning from Baby Steps
Basic muscle movement patterns during walking are preserved between newborn and adult humans.
