07 December 2011
Vol 3, Issue 112

About The Cover

Cover image expansion

ONLINE COVER Mind the Gap. A section of a mouse aorta shows dark purple vascular smooth muscle cells embedded in the pink artery lumen. In this issue of Science Translational Medicine, Huynh et al. show that when arteries stiffen with age, endothelial cells lose their connectivity and create gaps that allow the passage of cells and small molecules. Such leaky vasculature can lead to the development of atherosclerotic plaques. Luckily, the authors propose a way to close these gaps and treat age-related atherosclerosis by targeting the Rho kinase (ROCK) pathway. See also the related Focus by Lauffenburger. [CREDIT: J. PELOQUIN AND C. REINHART-KING/CORNELL UNIVERSITY]