30 November 2011
Vol 3, Issue 111

About The Cover

Cover image expansion

ONLINE COVER Circle of Cancer. This picture of a tumor genome is at the heart of the personalized cancer treatment described by Roychowdhury et al. in this issue. By quickly sequencing normal and tumor DNA and RNA (in 3 to 4 weeks) from patients with colorectal and prostate cancer, the authors could summarize the key genetic defects of the tumor (blue lines, intrachromosomal rearrangements; yellow lines, inversions; orange lines, interchromosomal rearrangements). A board of experts then recommended suitable therapy, tailored for the specific mutations identified.  [CREDIT:  B. STRAUCH/SCIENCE TRANSLATIONAL MEDICINE, ADAPTED FROM FIG. 3E BY L. SAM/UNIVERSITY OF MICHIGAN]