Research ArticleRadiation Toxicity

Bactericidal/Permeability-Increasing Protein (rBPI21) and Fluoroquinolone Mitigate Radiation-Induced Bone Marrow Aplasia and Death

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Science Translational Medicine  23 Nov 2011:
Vol. 3, Issue 110, pp. 110ra118
DOI: 10.1126/scitranslmed.3003126

Article Information

vol. 3 no. 110 110ra118

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 25, 2011
  • Accepted for publication October 27, 2011
  • .

Author Information

  1. Eva C. Guinan1,2,3,4,*,
  2. Christine M. Barbon5,
  3. Leslie A. Kalish6,
  4. Kalindi Parmar1,
  5. Jeff Kutok7,,
  6. Christy J. Mancuso8,
  7. Liat Stoler-Barak8,,
  8. Eugénie E. Suter8,§,
  9. Janice D. Russell1,
  10. Christine D. Palmer8,
  11. Leighanne C. Gallington8,||,
  12. Annie Voskertchian5,
  13. Jo-Anne Vergilio9,
  14. Geoffrey Cole5,
  15. Kaya Zhu1,
  16. Alan D’Andrea1,3,
  17. Robert Soiffer5,10,
  18. Jerrold P. Weiss11 and
  19. Ofer Levy8,12,13
  1. 1Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  2. 2Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  3. 3Department of Radiation Oncology, Harvard Medical School, Boston, MA 02115, USA.
  4. 4Division of Hematology/Oncology, Children’s Hospital Boston, Boston, MA 02115, USA.
  5. 5Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  6. 6Clinical Research Program, Children’s Hospital Boston, Boston, MA 02115, USA.
  7. 7Department of Pathology, Brigham and Women’s Hospital, Boston, MA 02115, USA.
  8. 8Division of Infectious Diseases, Children’s Hospital Boston, Boston, MA 02115, USA.
  9. 9Department of Pathology, Children’s Hospital Boston, Boston, MA 02115, USA.
  10. 10Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  11. 11Inflammation Program and Department of Medicine, University of Iowa, Coralville, IA 52241, USA.
  12. 12Leder Human Biology and Translational Medicine Program, Harvard Medical School, Boston, MA 02115, USA.
  13. 13Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
  1. *To whom correspondence should be addressed. E-mail: eva_guinan{at}dfci.harvard.edu

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