Contents
Vol 3, Issue 110
Contents
Focus
- Glowing Tumors Make for Better Detection and Resection
Tumor-specific fluorescent probes that can be administered topically make tumors selectively fluorescent and thus have great potential for improving cancer detection and removal.
Commentary
- Engineering Efficient Technology Transfer
Academic and industry leaders strategize for efficient translation of university-driven biomedical engineering innovations.
Research Articles
- Bactericidal/Permeability-Increasing Protein (rBPI21) and Fluoroquinolone Mitigate Radiation-Induced Bone Marrow Aplasia and Death
Even when given 24 hours after lethal radiation, a fragment of an endotoxin-neutralizing protein plus a fluoroquinolone antibiotic improves survival and hematopoietic recovery in mice.
- Rapid Cancer Detection by Topically Spraying a γ-Glutamyltranspeptidase–Activated Fluorescent Probe
A spirocyclic-caged, small-molecule imaging probe fluoresces upon cleavage by a cancer-specific enzyme and can be used during surgical or endoscopic tumor removal procedures.
Editors' Choice
- Quenching Flare-Ups
Cytomegalovirus confers resistance to immunosuppressive therapy in ulcerative colitis.
- Leukemia: The Master Vampire
Secretion of VEGF by leukemia cells involves the activation of the FMS-like tyrosine kinase-3 pathway.
- Lights Off—But Is Somebody Home?
High-resolution EEG reveals consciousness in patients diagnosed with vegetative state by current behavioral criteria.
- A Joint Venture Between Complement and Chondrocytes
Inflammation plays an unexpected complementary role in trauma-induced joint disease.
Podcast
- Science Translational Medicine Podcast: 23 November 2011
Dr. Kenneth Lutchen discusses biomedical engineering innovation, technology transfer, and ways of "winning the future."