23 November 2011
Vol 3, Issue 110

About The Cover

Cover image expansion

ONLINE COVER Tumors, Take Your Mark…Get Set…Glow! Tiny tumors light up in the mesentery of the peritoneal cavity—a location where ovarian cancers typically relocate in a process called metastasis. In this issue of Science Translational Medicine, Urano and colleagues describe an enzyme-activatable fluorescent probe that only glows when it encounters human ovarian cancer cells. Because the probe can be sprayed on a tumor-ridden region, surgeons can use this to illuminate hard-to-see tumors, for more complete removal.  See related Focus by Bouvet and Hoffman. [CREDIT: HISATAKA KOBAYASHI/MOLECULAR IMAGING PROGRAM/NATIONAL CANCER INSTITUTE/NATIONAL INSTITUTES OF HEALTH]