Contents

Contents

• Focus

  • Glowing Tumors Make for Better Detection and Resection

    By Michael Bouvet, Robert M. Hoffman

    Science Translational Medicine23 Nov 2011 : 110fs10 Full AccessRestricted Access

    Tumor-specific fluorescent probes that can be administered topically make tumors selectively fluorescent and thus have great potential for improving cancer detection and removal.

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• Commentary

  • Engineering Efficient Technology Transfer

    By Kenneth Lutchen, Jennifer Ayers, Sean Gallagher, Laith Abu-Taleb

    Science Translational Medicine23 Nov 2011 : 110cm32 Full AccessRestricted Access

    Academic and industry leaders strategize for efficient translation of university-driven biomedical engineering innovations.

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• Research Articles

  • Bactericidal/Permeability-Increasing Protein (rBPI₂₁) and Fluoroquinolone Mitigate Radiation-Induced Bone Marrow Aplasia and Death

    By Eva C. Guinan, Christine M. Barbon, Leslie A. Kalish, Kalindi Parmar, Jeff Kutok, Christy J. Mancuso, Liat Stoler-Barak, Eugénie E. Suter, Janice D. Russell, Christine D. Palmer, Leighanne C. Gallington, Annie Voskertchian, Jo-Anne Vergilio, Geoffrey Cole, Kaya Zhu, Alan D’Andrea, Robert Soiffer, Jerrold P. Weiss, Ofer Levy

    Science Translational Medicine23 Nov 2011 : 110ra118 Full AccessRestricted Access

    Even when given 24 hours after lethal radiation, a fragment of an endotoxin-neutralizing protein plus a fluoroquinolone antibiotic improves survival and hematopoietic recovery in mice.

    • Editor's Summary
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  • Rapid Cancer Detection by Topically Spraying a γ-Glutamyltranspeptidase–Activated Fluorescent Probe

    By Yasuteru Urano, Masayo Sakabe, Nobuyuki Kosaka, Mikako Ogawa, Makoto Mitsunaga, Daisuke Asanuma, Mako Kamiya, Matthew R. Young, Tetsuo Nagano, Peter L. Choyke, Hisataka Kobayashi

    Science Translational Medicine23 Nov 2011 : 110ra119 Full AccessRestricted Access

    A spirocyclic-caged, small-molecule imaging probe fluoresces upon cleavage by a cancer-specific enzyme and can be used during surgical or endoscopic tumor removal procedures.

    • Editor's Summary
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• Editors' Choice

  • Quenching Flare-Ups

    By Rebecca S. Boxer

    Science Translational Medicine23 Nov 2011 : 110ec188 Full AccessRestricted Access

    Cytomegalovirus confers resistance to immunosuppressive therapy in ulcerative colitis.

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  • Leukemia: The Master Vampire

    By Ashkan Emadi

    Science Translational Medicine23 Nov 2011 : 110ec189 Full AccessRestricted Access

    Secretion of VEGF by leukemia cells involves the activation of the FMS-like tyrosine kinase-3 pathway.

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  • Lights Off—But Is Somebody Home?

    By George A. Mashour

    Science Translational Medicine23 Nov 2011 : 110ec190 Full AccessRestricted Access

    High-resolution EEG reveals consciousness in patients diagnosed with vegetative state by current behavioral criteria.

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  • A Joint Venture Between Complement and Chondrocytes

    By Anthony K. Shum

    Science Translational Medicine23 Nov 2011 : 110ec191 Full AccessRestricted Access

    Inflammation plays an unexpected complementary role in trauma-induced joint disease.

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• Podcast

  • Science Translational Medicine Podcast: 23 November 2011

    By Kenneth Lutchen, Kelly LaMarco

    Science Translational Medicine23 Nov 2011 : 110pc13 Full AccessRestricted Access

    Dr. Kenneth Lutchen discusses biomedical engineering innovation, technology transfer, and ways of "winning the future."

    • Abstract