Contents
Vol 3, Issue 109
Contents
Focus
- Biomarker-Based Early Cancer Detection: Is It Achievable?
A new mathematical model evaluates the power of blood-based biomarkers for early cancer detection.
Perspective
- Targeting Chaperone-Mediated Autophagy in Cancer
Tumors need chaperone-mediated autophagy for growth and metastasis.
Research Articles
- Treatment and Prevention of Urinary Tract Infection with Orally Active FimH Inhibitors
Optimized mannoside compounds that block uropathogenic E. coli entry into bladder epithelium were effective in the treatment and prevention of urinary tract infections in mice.
- Mathematical Model Identifies Blood Biomarker–Based Early Cancer Detection Strategies and Limitations
Early cancer detection using current clinical blood-based biomarker assays may not be possible within the first 10 years of tumor growth.
- Chaperone-Mediated Autophagy Is Required for Tumor Growth
Cancer cells depend on chaperone-mediated autophagy for growth, revealing a new target for preventing tumorigenesis and inducing tumor regression.
Editors' Choice
- Suicide Genes Breathe New Life into Cell Therapies
A suicide gene can kill harmful alloreactive donor T cells in patients undergoing stem cell transplantation for relapsed acute leukemia.
- The Skeleton Key for Intracellular Pathogens: Nanoparticles and Pulmonary Vaccination
A nanoparticle-linked antigen induces cytotoxic T cell responses and protective immunity against influenza in mice.
- Brain Stimulation and Decision-Making
Experiments probe the effect of deep brain stimulation on the neural circuitry for decision-making and impulsive behavioral control.
