Research ArticleNeuroblastoma

Differential Inhibitor Sensitivity of Anaplastic Lymphoma Kinase Variants Found in Neuroblastoma

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Science Translational Medicine  09 Nov 2011:
Vol. 3, Issue 108, pp. 108ra114
DOI: 10.1126/scitranslmed.3002950

Article Information

vol. 3 no. 108 108ra114

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication July 21, 2011
  • Accepted for publication September 30, 2011

Author Information

  1. Scott C. Bresler1,2,3,*,
  2. Andrew C. Wood4,5,*,
  3. Elizabeth A. Haglund4,5,
  4. Joshua Courtright4,5,
  5. Lili T. Belcastro4,5,
  6. Jefferson S. Plegaria4,5,
  7. Kristina Cole4,5,
  8. Yana Toporovskaya4,5,
  9. Huaqing Zhao5,6,
  10. Erica L. Carpenter4,5,
  11. James G. Christensen7,
  12. John M. Maris4,5,8,
  13. Mark A. Lemmon1,2, and
  14. Yaël P. Mossé4,5,
  1. 1Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104–6059, USA.
  2. 2Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  3. 3Medical Scientist Training Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  4. 4Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  5. 5Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  6. 6Biostatistics and Data Management Core, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  7. 7Department of Cancer Research, Pfizer Global Research and Development, La Jolla Laboratories, La Jolla, CA 92121, USA.
  8. 8Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  1. To whom correspondence should be addressed. E-mail: mosse{at}email.chop.edu (Y.P.M.); mlemmon{at}mail.med.upenn.edu (M.A.L.)

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