Contents
Vol 3, Issue 108
Contents
Focus
- C-Path: A Watson-Like Visit to the Pathology Lab
Computer-based quantification of tumor morphology has arguably solved the problem of standardized tumor grading.
Perspective
- Harmonization of Immune Biomarker Assays for Clinical Studies
Harmonizing immune assay use in clinical trials could reduce data variability and support immune biomarker development.
Research Articles
- A Peptidomimetic Targeting White Fat Causes Weight Loss and Improved Insulin Resistance in Obese Monkeys
A peptide-based drug that targets the vasculature of adipose tissue induces weight loss and improves metabolic function in spontaneously obese monkeys.
- Systematic Analysis of Breast Cancer Morphology Uncovers Stromal Features Associated with Survival
Automated quantification of thousands of morphologic features in microscopic images of breast cancer allows the construction of a robust prognostic model.
- Differential Inhibitor Sensitivity of Anaplastic Lymphoma Kinase Variants Found in Neuroblastoma
Neuroblastoma sensitivity to crizotinib depends on the ATP-binding affinity of ALK variants, suggesting that higher doses may overcome resistance.
Editors' Choice
- An Oncogene Arises
A new candidate oncogene for ovarian cancer emerges from a genome-wide scan of both common and rare genetic variants.
- Yo-Yo Dieting: Biology or Behavior?
Patient study identifies changes in key metabolic hormones that may promote weight regain after dieting.
- A Supplement to Treat Diabetes?
Nicotinamide mononucleotide reverses defects in NAD+ biosynthesis and glucose metabolism in mice with type 2 diabetes.
- Genetic Markers of In-Stent Thrombosis
Variants of genes involved in drug metabolism and coagulation can predict the risk of in-stent thrombosis after coronary angiography.
- Engineering Connections
Bioengineered blood vessels can connect with host blood vessels after transplantation.
