Contents

Contents

• Focus

  • C-Path: A Watson-Like Visit to the Pathology Lab

    By David L. Rimm

    Science Translational Medicine09 Nov 2011 : 108fs8 Full AccessRestricted Access

    Computer-based quantification of tumor morphology has arguably solved the problem of standardized tumor grading.

    • Abstract
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• Perspective

  • Harmonization of Immune Biomarker Assays for Clinical Studies

    By Sjoerd H. van der Burg, Michael Kalos, Cécile Gouttefangeas, Sylvia Janetzki, Christian Ottensmeier, Marij J. P. Welters, Pedro Romero, Cedrik M. Britten, Axel Hoos

    Science Translational Medicine09 Nov 2011 : 108ps44 Full AccessRestricted Access

    Harmonizing immune assay use in clinical trials could reduce data variability and support immune biomarker development.

    • Abstract
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• Research Articles

  • A Peptidomimetic Targeting White Fat Causes Weight Loss and Improved Insulin Resistance in Obese Monkeys

    By Kirstin F. Barnhart, Dawn R. Christianson, Patrick W. Hanley, Wouter H. P. Driessen, Bruce J. Bernacky, Wallace B. Baze, Sijin Wen, Mei Tian, Jingfei Ma, Mikhail G. Kolonin, Pradip K. Saha, Kim-Anh Do, James F. Hulvat, Juri G. Gelovani, Lawrence Chan, Wadih Arap, Renata Pasqualini

    Science Translational Medicine09 Nov 2011 : 108ra112 Full AccessRestricted Access

    A peptide-based drug that targets the vasculature of adipose tissue induces weight loss and improves metabolic function in spontaneously obese monkeys.

    • Editor's Summary
    • Abstract
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  • Systematic Analysis of Breast Cancer Morphology Uncovers Stromal Features Associated with Survival

    By Andrew H. Beck, Ankur R. Sangoi, Samuel Leung, Robert J. Marinelli, Torsten O. Nielsen, Marc J. van de Vijver, Robert B. West, Matt van de Rijn, Daphne Koller

    Science Translational Medicine09 Nov 2011 : 108ra113 Full AccessRestricted Access

    Automated quantification of thousands of morphologic features in microscopic images of breast cancer allows the construction of a robust prognostic model.

    • Editor's Summary
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  • Differential Inhibitor Sensitivity of Anaplastic Lymphoma Kinase Variants Found in Neuroblastoma

    By Scott C. Bresler, Andrew C. Wood, Elizabeth A. Haglund, Joshua Courtright, Lili T. Belcastro, Jefferson S. Plegaria, Kristina Cole, Yana Toporovskaya, Huaqing Zhao, Erica L. Carpenter, James G. Christensen, John M. Maris, Mark A. Lemmon, Yaël P. Mossé

    Science Translational Medicine09 Nov 2011 : 108ra114 Full AccessRestricted Access

    Neuroblastoma sensitivity to crizotinib depends on the ATP-binding affinity of ALK variants, suggesting that higher doses may overcome resistance.

    • Editor's Summary
    • Abstract
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• Editors' Choice

  • An Oncogene Arises

    By Samir Damani

    Science Translational Medicine09 Nov 2011 : 108ec179 Full AccessRestricted Access

    A new candidate oncogene for ovarian cancer emerges from a genome-wide scan of both common and rare genetic variants.

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  • Yo-Yo Dieting: Biology or Behavior?

    By Carmella Evans-Molina

    Science Translational Medicine09 Nov 2011 : 108ec180 Full AccessRestricted Access

    Patient study identifies changes in key metabolic hormones that may promote weight regain after dieting.

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  • A Supplement to Treat Diabetes?

    By Diane Gesty-Palmer

    Science Translational Medicine09 Nov 2011 : 108ec181 Full AccessRestricted Access

    Nicotinamide mononucleotide reverses defects in NAD⁺ biosynthesis and glucose metabolism in mice with type 2 diabetes.

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  • Genetic Markers of In-Stent Thrombosis

    By Richard J. Lin

    Science Translational Medicine09 Nov 2011 : 108ec182 Full AccessRestricted Access

    Variants of genes involved in drug metabolism and coagulation can predict the risk of in-stent thrombosis after coronary angiography.

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  • Engineering Connections

    By Christopher Skelly

    Science Translational Medicine09 Nov 2011 : 108ec183 Full AccessRestricted Access

    Bioengineered blood vessels can connect with host blood vessels after transplantation.

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