Contents

Contents

• Focus

  • Epstein-Barr Virus: An Important Vaccine Target for Cancer Prevention

    By Jeffrey I. Cohen, Anthony S. Fauci, Harold Varmus, Gary J. Nabel

    Science Translational Medicine02 Nov 2011 : 107fs7 Full AccessRestricted Access

    Clinical studies should focus on prevention of Epstein-Barr virus–associated cancers and infectious mononucleosis, facilitated by identification of disease-predictive surrogate markers.

    • Abstract
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• Perspective

  • Epigenetics of Nicotine: Another Nail in the Coughing

    By Nora D. Volkow

    Science Translational Medicine02 Nov 2011 : 107ps43 Full AccessRestricted Access

    Chronic nicotine exposure rewired the brains of rodents and enhanced their behavioral response to cocaine.

    • Abstract
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• Research Articles

  • Molecular Mechanism for a Gateway Drug: Epigenetic Changes Initiated by Nicotine Prime Gene Expression by Cocaine

    By Amir Levine, YanYou Huang, Bettina Drisaldi, Edmund A. Griffin, Jr., Daniela D. Pollak, Shiqin Xu, Deqi Yin, Christine Schaffran, Denise B. Kandel, Eric R. Kandel

    Science Translational Medicine02 Nov 2011 : 107ra109 Full AccessRestricted Access

    The finding that nicotine enhances the brain’s response to cocaine may explain how smoking acts as a gateway drug for this addictive stimulant.

    • Editor's Summary
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  • Lipotoxicity Causes Multisystem Organ Failure and Exacerbates Acute Pancreatitis in Obesity

    By Sarah Navina, Chathur Acharya, James P. DeLany, Lidiya S. Orlichenko, Catherine J. Baty, Sruti S. Shiva, Chandra Durgampudi, Jenny M. Karlsson, Kenneth Lee, Kyongtae T. Bae, Alessandro Furlan, Jaideep Behari, Shiguang Liu, Teresa McHale, Larry Nichols, Georgios Ioannis Papachristou, Dhiraj Yadav, Vijay P. Singh

    Science Translational Medicine02 Nov 2011 : 107ra110 Full AccessRestricted Access

    Unsaturated fatty acids cause lipotoxicity and mediate acute adverse outcomes in obese individuals with pancreatitis.

    • Editor's Summary
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  • ALDH2 Activator Inhibits Increased Myocardial Infarction Injury by Nitroglycerin Tolerance

    By Lihan Sun, Julio Cesar Batista Ferreira, Daria Mochly-Rosen

    Science Translational Medicine02 Nov 2011 : 107ra111 Full AccessRestricted Access

    Tolerance to nitroglycerin, a drug often used to treat chest pain, increases susceptibility to injury by myocardial infarction.

    • Editor's Summary
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• Editors' Choice

  • Tuning In to Gene-Environment Synergy

    By Carrie M. Nielson

    Science Translational Medicine02 Nov 2011 : 107ec176 Full AccessRestricted Access

    Information theory facilitates analyses of complex gene-gene and gene-environment interactions.

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  • All in the Family

    By Timothy B. Niewold

    Science Translational Medicine02 Nov 2011 : 107ec177 Full AccessRestricted Access

    Defective DNA clearance enzyme leads to monogenic familial lupus.

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  • Roaming Cancers Are Cooked

    By Srini Tridandapani

    Science Translational Medicine02 Nov 2011 : 107ec178 Full AccessRestricted Access

    Microwaves can ablate tumors that have metastasized to lungs and improve survival in patients.

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