Contents
Vol 3, Issue 107
Contents
Focus
- Epstein-Barr Virus: An Important Vaccine Target for Cancer Prevention
Clinical studies should focus on prevention of Epstein-Barr virus–associated cancers and infectious mononucleosis, facilitated by identification of disease-predictive surrogate markers.
Perspective
- Epigenetics of Nicotine: Another Nail in the Coughing
Chronic nicotine exposure rewired the brains of rodents and enhanced their behavioral response to cocaine.
Research Articles
- Molecular Mechanism for a Gateway Drug: Epigenetic Changes Initiated by Nicotine Prime Gene Expression by Cocaine
The finding that nicotine enhances the brain’s response to cocaine may explain how smoking acts as a gateway drug for this addictive stimulant.
- Lipotoxicity Causes Multisystem Organ Failure and Exacerbates Acute Pancreatitis in Obesity
Unsaturated fatty acids cause lipotoxicity and mediate acute adverse outcomes in obese individuals with pancreatitis.
- ALDH2 Activator Inhibits Increased Myocardial Infarction Injury by Nitroglycerin Tolerance
Tolerance to nitroglycerin, a drug often used to treat chest pain, increases susceptibility to injury by myocardial infarction.
Editors' Choice
- Tuning In to Gene-Environment Synergy
Information theory facilitates analyses of complex gene-gene and gene-environment interactions.
- Roaming Cancers Are Cooked
Microwaves can ablate tumors that have metastasized to lungs and improve survival in patients.