26 October 2011
Vol 3, Issue 106
  • Contents

    • Perspectives

    • Research Articles

      • The Impact of a Consortium of Fermented Milk Strains on the Gut Microbiome of Gnotobiotic Mice and Monozygotic Twins

        Metagenomic analyses of gnotobiotic mice and monozygotic twins reveal the effects of eating a popular fermented milk product on their microbiomes.

      • Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging

        Antisense oligonucleotides reverse premature aging and extend life span in mutant mice that mimic aberrant splicing in progeria patients.

      • Preclinical and Clinical Evaluation of Intraductally Administered Agents in Early Breast Cancer

        Intraductal administration of chemotherapeutic agents may reduce new breast cancer formation and offer a less toxic treatment regimen than intravenous therapy.

    • Editors' Choice

      • Tackling TIA

        A 34-gene expression signature identifies patients who have suffered a transient ischemic attack with 100% sensitivity and 100% specificity.

      • With This Ring

        Messenger RNA splicing mutations are frequent in myelodysplastic syndromes with ring sideroblasts and predict better prognosis and survival.

      • Food for Nanoworms

        Linked peptides target brain tumor blood vessels for destruction while sparing healthy brain tissue.

      • Helping the Heart to Heal

        Liposomes targeted to an angiotensin receptor promote the delivery of drugs to the damaged heart.

      • Refreshing Your Memory

        A subset of human memory T cells with stem cell-like properties may provide a durable antitumor response.

    • Podcast

About The Cover

Cover image expansion

ONLINE COVER A Spoonful of Yogurt. Certain types of yogurt contain probiotic bacterial species that are believed to confer health benefits, such as improved digestion, when the yogurt is consumed. A big question is whether the bacterial species in probiotic yogurt exert their health benefits by directly affecting the vast population of microbes that normally inhabit our gut. McNulty et al. tackle this daunting question by feeding a probiotic yogurt to seven pairs of identical twins over 7 weeks and sequencing the bacterial species in their feces to see whether the composition of the indigenous bacterial species had changed after yogurt consumption. They discovered that the probiotic bacteria in the yogurt did not take up residence in the gut or alter the normal composition of the twins’ gut microbiome, but did induce changes in the metabolic genes expressed by the indigenous microbes. This suggests that the beneficial effects of probiotic yogurt may be exerted through subtle changes in the metabolism of the existing gut microbiome. [CREDIT: FOTOSEARCH]