Contents
Vol 3, Issue 105
Contents
Focus
- Containing the Contagion: Treating the Virus That Inspired the Film
Postexposure passive immunotherapy protects African green monkeys from lethal challenge with Contagion-related Hendra virus.
Perspective
- Hedgehog Rushes to the Rescue of the Developing Cerebellum
A small molecule that targets the sonic hedgehog pathway tempers the thwarting of cerebellar growth by steroids in premature newborns.
Research Articles
- A Neutralizing Human Monoclonal Antibody Protects African Green Monkeys from Hendra Virus Challenge
A neutralizing human monoclonal antibody can fully protect nonhuman primates from disease after a lethal Hendra virus challenge.
- A Small-Molecule Smoothened Agonist Prevents Glucocorticoid-Induced Neonatal Cerebellar Injury
A Sonic hedgehog–Smoothened signaling agonist can protect against brain injury in mice caused by glucocorticoids, which are given to treat chronic lung disease in preterm infants.
- Preterm Cerebellar Growth Impairment After Postnatal Exposure to Glucocorticoids
Glucocorticoid exposure in preterm newborns is associated with impaired cerebellar development, pointing to a modifiable risk factor for improving motor and cognitive outcomes after premature birth.
Editors' Choice
- ARRESTINg Obesity
A new arrestin family–signaling protein regulates obesity and energy expenditure in mice and humans by a gender-sensitive mechanism.
- The Great Escape
The tryptophan degradation product kynurenine suppresses the antitumor immune response and enhances tumor cell survival.
- Delving Deeper into the Persistent Mysteries of Tuberculosis
A study using deep sequencing to characterize transposon libraries demonstrates that cholesterol catabolism genes are essential for growth of Mycobacterium tuberculosis.