Contents

Contents

• Focus

  • Containing the Contagion: Treating the Virus That Inspired the Film

    By Benhur Lee

    Science Translational Medicine19 Oct 2011 : 105fs6 Full AccessRestricted Access

    Postexposure passive immunotherapy protects African green monkeys from lethal challenge with Contagion-related Hendra virus.

    • Abstract
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• Perspective

  • Hedgehog Rushes to the Rescue of the Developing Cerebellum

    By Olivier Baud, Pierre Gressens

    Science Translational Medicine19 Oct 2011 : 105ps40 Full AccessRestricted Access

    A small molecule that targets the sonic hedgehog pathway tempers the thwarting of cerebellar growth by steroids in premature newborns.

    • Abstract
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• Research Articles

  • A Neutralizing Human Monoclonal Antibody Protects African Green Monkeys from Hendra Virus Challenge

    By Katharine N. Bossart, Thomas W. Geisbert, Heinz Feldmann, Zhongyu Zhu, Friederike Feldmann, Joan B. Geisbert, Lianying Yan, Yan-Ru Feng, Doug Brining, Dana Scott, Yanping Wang, Antony S. Dimitrov, Julie Callison, Yee-Peng Chan, Andrew C. Hickey, Dimiter S. Dimitrov, Christopher C. Broder, Barry Rockx

    Science Translational Medicine19 Oct 2011 : 105ra103 Full AccessRestricted Access

    A neutralizing human monoclonal antibody can fully protect nonhuman primates from disease after a lethal Hendra virus challenge.

    • Editor's Summary
    • Abstract
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  • A Small-Molecule Smoothened Agonist Prevents Glucocorticoid-Induced Neonatal Cerebellar Injury

    By Vivi M. Heine, Amelie Griveau, Cheryl Chapin, Philip L. Ballard, James K. Chen, David H. Rowitch

    Science Translational Medicine19 Oct 2011 : 105ra104 Full AccessRestricted Access

    A Sonic hedgehog–Smoothened signaling agonist can protect against brain injury in mice caused by glucocorticoids, which are given to treat chronic lung disease in preterm infants.

    • Editor's Summary
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  • Preterm Cerebellar Growth Impairment After Postnatal Exposure to Glucocorticoids

    By Emily W. Y. Tam, Vann Chau, Donna M. Ferriero, A. James Barkovich, Kenneth J. Poskitt, Colin Studholme, Eric D.-Y. Fok, Ruth E. Grunau, David V. Glidden, Steven P. Miller

    Science Translational Medicine19 Oct 2011 : 105ra105 Full AccessRestricted Access

    Glucocorticoid exposure in preterm newborns is associated with impaired cerebellar development, pointing to a modifiable risk factor for improving motor and cognitive outcomes after premature birth.

    • Editor's Summary
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• Editors' Choice

  • ARRESTINg Obesity

    By Mickie Cheng

    Science Translational Medicine19 Oct 2011 : 105ec168 Full AccessRestricted Access

    A new arrestin family–signaling protein regulates obesity and energy expenditure in mice and humans by a gender-sensitive mechanism.

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  • The Great Escape

    By David S. Hong

    Science Translational Medicine19 Oct 2011 : 105ec169 Full AccessRestricted Access

    The tryptophan degradation product kynurenine suppresses the antitumor immune response and enhances tumor cell survival.

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  • Delving Deeper into the Persistent Mysteries of Tuberculosis

    By Melissa Nyendak

    Science Translational Medicine19 Oct 2011 : 105ec170 Full AccessRestricted Access

    A study using deep sequencing to characterize transposon libraries demonstrates that cholesterol catabolism genes are essential for growth of Mycobacterium tuberculosis.

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