12 October 2011
Vol 3, Issue 104
  • Contents

    • Editorial

      • A Rattle Bag of Science and the Art of Translation

        Science Translational Medicine’s new Co–Chief Scientific Advisors define translational science and articulate their vision for the journal.

    • Commentary

      • Medical Faculty Development: A Modern-Day Odyssey

        Academic medical centers must make systematic changes to improve the quality of life—and thus productivity—of their faculty.

    • Research Articles

      • Diabetes Impairs Hematopoietic Stem Cell Mobilization by Altering Niche Function

        Impaired mobilization of hematopoietic stem cells in diabetic mice is due to sympathetic nervous system dysregulation of CXCL12 distribution.

      • Vitamin D Is Required for IFN-γ–Mediated Antimicrobial Activity of Human Macrophages

        Vitamin D is required for both innate and adaptive immunity to tuberculosis.

    • Editors' Choice

      • Individualizing Asthma Treatment

        A genome-wide association study identifies a new predictive genetic variant for response to a common asthma treatment.

      • Spotlight on the Silent Lady Killer

        A new method fluorescently labels ovarian tumors for easy surgical removal.

      • Molecular Clue to Disease Prognosis

        Genetic signatures may help to risk-stratify a heterogeneous precancerous blood disorder.

      • Going Viral

        Human cytomegalovirus may potentially cause, and thus be targeted to treat, some medulloblastomas.

About The Cover

Cover image expansion

ONLINE COVER A Thousand Points of Light. Multiple color fluorescent staining shows a high percentage of T helper 17 (TH17) cells [yellow–merge of T cells (red) and interleukin-17 (green)] in colon cancer tissue (nuclei, blue). Kryczek et al. demonstrated that human TH17 cells function as long-lived effector memory cells in the context of chronic disease and cancer. Targeting these long-lived cells could have beneficial effects in treating autoimmune disease and promoting antitumor immunity. [CREDIT: I. KRYCZEK AND W. ZOU/THE UNIVERISTY OF MICHIGAN]