Contents
Vol 3, Issue 102
Contents
Focus
- Creating the Future Biomedical Research Workforce
As an NIH task force ponders the future of the U.S. biomedical workforce, clinical and translational scientists can contribute crucial insights.
Commentary
- Disclosure of Clinical Trial Results When Product Development Is Abandoned
Researchers have an ethical obligation to publicly report clinical trial results for all products.
Research Articles
- Dendritic Cells Regulate Natural Killer Cell Activation and Epithelial Injury in Experimental Biliary Atresia
Plasmacytoid and conventional dendritic cells both contribute to natural killer cell activation and epithelial tissue injury in a mouse model of biliary atresia.
- Computationally Generated Cardiac Biomarkers for Risk Stratification After Acute Coronary Syndrome
Computational biomarkers extracted by machine learning from electrocardiograms improve identification of high-risk patients after coronary events.
- Reversible Cardiac Conduction Block and Defibrillation with High-Frequency Electric Field
High-frequency electric fields partially depolarize myocardial cells, inducing a reversible refractory state that terminates reentrant arrhythmias.
Editors' Choice
- Biomarking Bad Outcomes
Markers of collagen turnover reveal increased risk of heart attack and death.
- Stem Cells: The Good, the Bad, and the Ugly
Survival of leukemia patients can be predicted based on the gene expression signatures of leukemia and hematopoietic stem cells.
- Teaching the Fetal Hypothalamus
Synchronization of gene expression between the placenta and fetal hypothalamus may transmit maternal responses through generations and regulate reproductive functions.
- More than Just “Getting In”
A dual-targeting strategy promotes the transport of nanoparticles across the blood-brain barrier and also directs them toward glial cells.
- Digesting the Unexpected Side Effects of Chronic Antibiotic Use
Chronic antibody use may block autophagy, increasing the risk of mycobacterial infection.
Podcast
- Science Translational Medicine Podcast: 28 September 2011
A conversation with Ronald Berger about using high-frequency alternating current to stop life-threatening ventricular fibrillation.
Meeting Reports
- Translating Glutamate: From Pathophysiology to Treatment
On 21 to 22 June 2010, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, discussed the role of glutamate in neuropsychiatric disease at the meeting “Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System.”
- Translational Neuroscience of Schizophrenia: Seeking a Meeting of Minds Between Mouse and Man
A meeting held 9 June 2011 in Helsinki, Finland, discussed the requirements for creating useful mouse models for schizophrenia.
Erratum
