Contents
Vol 3, Issue 100
Contents
Commentaries
- What Can a UN Health Summit Do?
A United Nations high level summit meeting on noncommunicable diseases will set priorities for addressing this major threat to the health of both developing and developed nations.
- Biomedical Innovation in Academic Institutions: Mitigating Conflict of Interest
Conflicts of interest around academic innovation must be managed if universities and their medical centers are to maintain the public trust.
Research Articles
- Gαs-Biased β2-Adrenergic Receptor Signaling from Restoring Synchronous Contraction in the Failing Heart
Synchronizing abnormal contraction in the failing hearts permanently alters β2-adrenergic signaling, pointing to a new therapeutic approach.
- Engineering the Growth Factor Microenvironment with Fibronectin Domains to Promote Wound and Bone Tissue Healing
A multifunctional fibronectin fragment enhances the regenerative effects of growth factors in vivo in animal models of chronic wounds and critical-size bone defects.
- Donor Myocardial Infarction Impairs the Therapeutic Potential of Bone Marrow Cells by an Interleukin-1–Mediated Inflammatory Response
Inflammation after myocardial infarction may explain failure of bone marrow cells to improve cardiac function in infarcted recipient hearts.
Editors' Choice
- The Genome and Metabolome Collide
A study of genomic variants and myriad metabolite concentrations reveals insights into disease biology and novel therapeutic targets.
- Ankyring the Heart Rhythm
Mutations in a membrane-targeting adaptor protein illuminate a molecular pathway in a common cardiac arrhythmia.
- HIV Under Cover
HIV replication by cell-to-cell spread enables the virus to evade destruction by antiretroviral drugs without developing drug-resistance mutations.
- Eureka!!! Sewing to Moonbeams
A thermoreversible nanopolymer enables a new method of creating sutureless vascular-vascular connections without trauma to the tissue.
