Meeting ReportsDrug Development

Development of the First Inhaled Antibiotic for the Treatment of Cystic Fibrosis

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Science Translational Medicine  22 Dec 2010:
Vol. 2, Issue 63, pp. 63mr4
DOI: 10.1126/scitranslmed.3001634

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Tobramycin Inhalation Solution USP (TOBI), a therapy developed to treat lung infections associated with cystic fibrosis (CF), was presented as a demonstration case for collaborative pharmaceutical development at a Clinical and Translational Science Awards Industry Forum on “Promoting Efficient and Effective Collaborations Among Academia, Government, and Industry” held in February 2010. TOBI was developed by PathoGenesis Corporation (Seattle, WA) in collaboration with the academic inventors, the National Institutes of Health, the U.S. Food and Drug Administration, and the CF Foundation. The presenters, representing the academic, industry, and foundation partners, each reviewed the program from their perspectives and identified challenges that existed during the discovery, development, and commercialization of TOBI. The attendees were asked to consider other collaborative opportunities that might have further improved TOBI development, including the optimal roles of the academic researchers, foundations, and other agencies when industry drives development and commercialization decisions.


  • Citation: L. M. Rose, R. Neale, Development of the First Inhaled Antibiotic for the Treatment of Cystic Fibrosis. Sci. Transl. Med. 2, 63mr4 (2010).

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