Contents
Vol 2, Issue 63
Contents
Editorial
- 2010: Awards Show What Translation Can Accomplish
Four of the most coveted awards in science celebrate truly translational research.
Commentary
- Advancing Translational Research Collaborations
A 2010 NIH forum investigated how barriers to collaboration among academia, government, and industry must be identified and overcome to maximize the clinical return on investment in science (see also the five accompanying meeting reports).
Research Article
- Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47
Calreticulin-induced phagocytosis of cancer cells can be counterbalanced by CD47 expression.
Reports
- Short-Term Monotherapy in HIV-Infected Patients with a Virus Entry Inhibitor Against the gp41 Fusion Peptide
An optimized derivative of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide shows antiviral potency and minimal side effects in a Phase I/II clinical trial.
Editors' Choice
- Targeting the Channel: CF Treatment Gets Personal
A drug that targets a specific mutated form of the protein that causes cystic fibrosis improves the protein’s function and disease symptoms.
- Insulin Resistance Results in Brain Drain
Insulin regulates brain cholesterol metabolism by modulating the expression of cholesterol-synthesizing enzymes in the central nervous system.
- Illuminating Drug Action in the Parkinsonian Brain
Functional MRI can be used to monitor the action of new drugs in the brains of Parkinson's disease patients.
- Tumor Endothelial Cells: Mixed Parentage
Cancer stem cells in glioblastoma multiforme give rise to a subset of tumor blood vessels.
Meeting Reports
- Training the Translational Scientist
A session about educating translational scientists was held at a 2010 NIH forum on promoting collaborations between academia, government, and industry.
- Collaborations Among Academia, Government, and Industry in the Diagnostics Space: Barriers and Some Ideas for Solutions
A session about the challenges that occur during diagnostics development was held at a 2010 NIH forum on promoting collaborations among academia, government, and industry.
- Development of the First Inhaled Antibiotic for the Treatment of Cystic Fibrosis
A session about the challenges that occur during drug development was held at a 2010 NIH forum on promoting collaborations among academia, government, and industry.
- Working with the CTSA Consortium: What We Bring to the Table
A session about how CTSA Consortium efforts can foster public-private partnerships was held at a 2010 NIH forum on promoting collaborations among academia, government, and industry.
- Academic/Industry Challenges for Medical Device Development
A session about the challenges that occur during medical device development was held at a 2010 NIH forum on promoting collaborations among academia, government, and industry.
