1Max Planck Institute for Neurological Research, Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, 50931 Cologne, Germany.
2Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne, Germany.
3Department I of Internal Medicine and Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne, Germany.
4Institute of Pathology, Comprehensive Cancer Center, University Hospital Tübingen, 72076 Tübingen, Germany.
5Institute for Surgical Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.
6Department of Surgery, Weill Medical College, Cornell University, New York, NY 10065, USA.
7Institute of Pathology, University of Bonn, 53123 Bonn, Germany.
8Chemical Genomics Center, Max Planck Society, 44227 Dortmund, Germany.
9Cologne Center for Genomics and Institute for Genetics, University of Cologne, 50931 Cologne, Germany.
10Department of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, 3002 Victoria, Australia.
11Department of Pathology, St. Vincent’s Hospital, Melbourne, 3065 Victoria, Australia.
12Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, 3002 Victoria, Australia.
13Department of Pathology, Université Joseph Fourier, 38041 Grenoble, France.
14Institut Albert Bonniot INSERM U823, Université Joseph Fourier, 38042 Grenoble, France.
15Department of Thoracic Surgery, Rikshospitalet, Oslo University Hospital, 0027 Oslo, Norway.
16Department of Radiation Biology, Norwegian Radium Hospital, N-0310 Oslo, Norway.
17Department of Oncology, Radiumhospitalet, Oslo University Hospital, N-0310 Oslo, Norway.
18Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne, Germany.
19Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena, Germany.
20Institute for Pathology Bad Berka, 99438 Bad Berka, Germany.
21Department for Internal Medicine II, University Clinic Jena, Friedrich-Schiller University, 07740 Jena, Germany.
22Department of Pulmonary Diseases, University Medical Centre Groningen, 9713 GZ Groningen, Netherlands.
23Department of Pathology, University Medical Centre Groningen, 9713 GZ Groningen, Netherlands.
24Department of Pathology, VU University Medical Center Amsterdam, 1007 MB Amsterdam, Netherlands.
25Department of Pulmonary Diseases, VU University Medical Center Amsterdam, 1007 MB Amsterdam, Netherlands.
26Department of Medical Oncology, Ospedale Civile, 57100 Livorno, Italy.
27Department of Haematology and Oncologic Science, University Hospital Bologna, 40138 Bologna, Italy.
28Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, 50931 Cologne, Germany.
29Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
30Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.
31Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
32Cancer Program, Broad Institute, Cambridge, MA 02115, USA.
33Vanderbilt-Ingram Cancer Center, Nashville, TN 37212, USA.
34Lead Discovery Center GmbH, 44227 Dortmund, Germany.
35Department of Pathology, Hospital Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne, Germany.
↵†To whom correspondence should be addressed. E-mail: martin.sos{at}nf.mpg.de (M.L.S.); nini{at}nf.mpg.de (R.K.T.)
↵* These authors contributed equally to this work.
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Science Translational Medicine 15 Dec 2010: Vol. 2, Issue 62, pp. 62ra93 DOI: 10.1126/scitranslmed.3001451
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Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer
By Jonathan Weiss, Martin L. Sos, Danila Seidel, Martin Peifer, Thomas Zander, Johannes M. Heuckmann, Roland T. Ullrich, Roopika Menon, Sebastian Maier, Alex Soltermann, Holger Moch, Patrick Wagener, Florian Fischer, Stefanie Heynck, Mirjam Koker, Jakob Schöttle, Frauke Leenders, Franziska Gabler, Ines Dabow, Silvia Querings, Lukas C. Heukamp, Hyatt Balke-Want, Sascha Ansén, Daniel Rauh, Ingelore Baessmann, Janine Altmüller, Zoe Wainer, Matthew Conron, Gavin Wright, Prudence Russell, Ben Solomon, Elisabeth Brambilla, Christian Brambilla, Philippe Lorimier, Steinar Sollberg, Odd Terje Brustugun, Walburga Engel-Riedel, Corinna Ludwig, Iver Petersen, Jörg Sänger, Joachim Clement, Harry Groen, Wim Timens, Hannie Sietsma, Erik Thunnissen, Egbert Smit, Daniëlle Heideman, Federico Cappuzzo, Claudia Ligorio, Stefania Damiani, Michael Hallek, Rameen Beroukhim, William Pao, Bert Klebl, Matthias Baumann, Reinhard Buettner, Karen Ernestus, Erich Stoelben, Jürgen Wolf, Peter Nürnberg, Sven Perner, Roman K. Thomas
Science Translational Medicine : 62ra93
FGFR1 amplification provides a therapeutic target for squamous cell lung cancer, which is resistant to other targeted lung cancer drugs.
Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer
By Jonathan Weiss, Martin L. Sos, Danila Seidel, Martin Peifer, Thomas Zander, Johannes M. Heuckmann, Roland T. Ullrich, Roopika Menon, Sebastian Maier, Alex Soltermann, Holger Moch, Patrick Wagener, Florian Fischer, Stefanie Heynck, Mirjam Koker, Jakob Schöttle, Frauke Leenders, Franziska Gabler, Ines Dabow, Silvia Querings, Lukas C. Heukamp, Hyatt Balke-Want, Sascha Ansén, Daniel Rauh, Ingelore Baessmann, Janine Altmüller, Zoe Wainer, Matthew Conron, Gavin Wright, Prudence Russell, Ben Solomon, Elisabeth Brambilla, Christian Brambilla, Philippe Lorimier, Steinar Sollberg, Odd Terje Brustugun, Walburga Engel-Riedel, Corinna Ludwig, Iver Petersen, Jörg Sänger, Joachim Clement, Harry Groen, Wim Timens, Hannie Sietsma, Erik Thunnissen, Egbert Smit, Daniëlle Heideman, Federico Cappuzzo, Claudia Ligorio, Stefania Damiani, Michael Hallek, Rameen Beroukhim, William Pao, Bert Klebl, Matthias Baumann, Reinhard Buettner, Karen Ernestus, Erich Stoelben, Jürgen Wolf, Peter Nürnberg, Sven Perner, Roman K. Thomas
Science Translational Medicine : 62ra93
FGFR1 amplification provides a therapeutic target for squamous cell lung cancer, which is resistant to other targeted lung cancer drugs.
