Research ArticleLUNG CANCER

Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer

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Science Translational Medicine  15 Dec 2010:
Vol. 2, Issue 62, pp. 62ra93
DOI: 10.1126/scitranslmed.3001451

Article Information

vol. 2 no. 62 62ra93

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication July 6, 2010
  • Accepted for publication November 24, 2010
  • .

Author Information

  1. Jonathan Weiss1,*,
  2. Martin L. Sos1,*,,
  3. Danila Seidel1,2,*,
  4. Martin Peifer1,
  5. Thomas Zander3,
  6. Johannes M. Heuckmann1,
  7. Roland T. Ullrich1,
  8. Roopika Menon4,
  9. Sebastian Maier4,
  10. Alex Soltermann5,
  11. Holger Moch5,
  12. Patrick Wagener6,
  13. Florian Fischer1,
  14. Stefanie Heynck1,
  15. Mirjam Koker1,
  16. Jakob Schöttle1,
  17. Frauke Leenders1,2,
  18. Franziska Gabler1,2,
  19. Ines Dabow1,2,
  20. Silvia Querings1,
  21. Lukas C. Heukamp7,
  22. Hyatt Balke-Want1,
  23. Sascha Ansén3,
  24. Daniel Rauh8,
  25. Ingelore Baessmann9,
  26. Janine Altmüller9,
  27. Zoe Wainer10,
  28. Matthew Conron10,
  29. Gavin Wright10,
  30. Prudence Russell11,
  31. Ben Solomon12,
  32. Elisabeth Brambilla13,14,
  33. Christian Brambilla13,14,
  34. Philippe Lorimier13,
  35. Steinar Sollberg15,
  36. Odd Terje Brustugun16,17,
  37. Walburga Engel-Riedel18,
  38. Corinna Ludwig18,
  39. Iver Petersen19,
  40. Jörg Sänger20,
  41. Joachim Clement21,
  42. Harry Groen22,
  43. Wim Timens23,
  44. Hannie Sietsma23,
  45. Erik Thunnissen24,
  46. Egbert Smit25,
  47. Daniëlle Heideman24,
  48. Federico Cappuzzo26,
  49. Claudia Ligorio27,
  50. Stefania Damiani27,
  51. Michael Hallek3,28,
  52. Rameen Beroukhim29,30,31,32,
  53. William Pao33,
  54. Bert Klebl34,
  55. Matthias Baumann34,
  56. Reinhard Buettner7,
  57. Karen Ernestus35,
  58. Erich Stoelben18,
  59. Jürgen Wolf2,3,
  60. Peter Nürnberg8,28,
  61. Sven Perner4 and
  62. Roman K. Thomas1,2,3,8,
  1. 1Max Planck Institute for Neurological Research, Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, 50931 Cologne, Germany.
  2. 2Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne, Germany.
  3. 3Department I of Internal Medicine and Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne, Germany.
  4. 4Institute of Pathology, Comprehensive Cancer Center, University Hospital Tübingen, 72076 Tübingen, Germany.
  5. 5Institute for Surgical Pathology, University Hospital Zurich, 8091 Zurich, Switzerland.
  6. 6Department of Surgery, Weill Medical College, Cornell University, New York, NY 10065, USA.
  7. 7Institute of Pathology, University of Bonn, 53123 Bonn, Germany.
  8. 8Chemical Genomics Center, Max Planck Society, 44227 Dortmund, Germany.
  9. 9Cologne Center for Genomics and Institute for Genetics, University of Cologne, 50931 Cologne, Germany.
  10. 10Department of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, 3002 Victoria, Australia.
  11. 11Department of Pathology, St. Vincent’s Hospital, Melbourne, 3065 Victoria, Australia.
  12. 12Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, 3002 Victoria, Australia.
  13. 13Department of Pathology, Université Joseph Fourier, 38041 Grenoble, France.
  14. 14Institut Albert Bonniot INSERM U823, Université Joseph Fourier, 38042 Grenoble, France.
  15. 15Department of Thoracic Surgery, Rikshospitalet, Oslo University Hospital, 0027 Oslo, Norway.
  16. 16Department of Radiation Biology, Norwegian Radium Hospital, N-0310 Oslo, Norway.
  17. 17Department of Oncology, Radiumhospitalet, Oslo University Hospital, N-0310 Oslo, Norway.
  18. 18Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne, Germany.
  19. 19Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena, Germany.
  20. 20Institute for Pathology Bad Berka, 99438 Bad Berka, Germany.
  21. 21Department for Internal Medicine II, University Clinic Jena, Friedrich-Schiller University, 07740 Jena, Germany.
  22. 22Department of Pulmonary Diseases, University Medical Centre Groningen, 9713 GZ Groningen, Netherlands.
  23. 23Department of Pathology, University Medical Centre Groningen, 9713 GZ Groningen, Netherlands.
  24. 24Department of Pathology, VU University Medical Center Amsterdam, 1007 MB Amsterdam, Netherlands.
  25. 25Department of Pulmonary Diseases, VU University Medical Center Amsterdam, 1007 MB Amsterdam, Netherlands.
  26. 26Department of Medical Oncology, Ospedale Civile, 57100 Livorno, Italy.
  27. 27Department of Haematology and Oncologic Science, University Hospital Bologna, 40138 Bologna, Italy.
  28. 28Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, 50931 Cologne, Germany.
  29. 29Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  30. 30Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.
  31. 31Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  32. 32Cancer Program, Broad Institute, Cambridge, MA 02115, USA.
  33. 33Vanderbilt-Ingram Cancer Center, Nashville, TN 37212, USA.
  34. 34Lead Discovery Center GmbH, 44227 Dortmund, Germany.
  35. 35Department of Pathology, Hospital Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne, Germany.
  1. To whom correspondence should be addressed. E-mail: martin.sos{at}nf.mpg.de (M.L.S.); nini{at}nf.mpg.de (R.K.T.)
  • * These authors contributed equally to this work.

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