A Therapeutic Target for Smoking-Associated Lung Cancer

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Science Translational Medicine  15 Dec 2010:
Vol. 2, Issue 62, pp. 62ps56
DOI: 10.1126/scitranslmed.3001942

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A report in this issue of Science Translational Medicine reveals that amplification of the FGFR1 gene—which encodes fibroblast growth factor receptor 1—is a major oncogenic aberration in squamous cell lung cancer. This genetic variation may represent the first relatively high-frequency therapeutic target of smoking-associated lung cancer.


  • Citation: N. C. Turner, M. J. Seckl, A therapeutic target for smoking-associated lung cancer. Sci. Transl. Med. 2, 62ps56 (2010).

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