15 December 2010
Vol 2, Issue 62

About The Cover

Cover image expansion

ONLINE COVER FISHing for FGFR1. The gene FGFR1 is amplified in these squamous cell lung carcinoma cells, as revealed by fluorescence in situ hybridization (red, fibroblast growth factor receptor 1; green, control reference probe; blue, nucleus). Squamous cell lung cancer, which commonly affects smokers, is resistant to many forms of chemotherapy. Weiss et al. found more copies of this receptor tyrosine kinase gene in cells from this kind of lung cancer than in normal tissue or other lung cancer subtypes. FGFR1 may provide a therapeutic target for squamous cell lung cancer. [CREDIT: S. PERNER/INSTITUTE OF PATHOLOGY, UNIVERSITY OF BONN]