ReviewMetabolic Disease

The Role of JNK Proteins in Metabolism

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Science Translational Medicine  01 Dec 2010:
Vol. 2, Issue 60, pp. 60rv5
DOI: 10.1126/scitranslmed.3001007

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The stress-activated c-Jun amino-terminal kinase (JNK) plays a pivotal role in metabolic conditions such as obesity, insulin resistance, and type 2 diabetes. Intricate tissue-specific tweaking of JNK activity in preclinical models of metabolic diseases reveals a complex interplay among local and systemic effects on carbohydrate and lipid metabolism. Synthesis of these entangled effects illustrates that for JNK inhibitors to have therapeutic impact, they must function in multiple cell types to modulate JNK activity.


  • Citation: S. N. Vallerie, G. S. Hotamisligil, The Role of JNK Proteins in Metabolism. Sci. Transl.Med. 2, 60rv5 (2010).

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