Research ArticleLysosomal Storage Diseases

Replacing the Enzyme α-l-Iduronidase at Birth Ameliorates Symptoms in the Brain and Periphery of Dogs with Mucopolysaccharidosis Type I

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Science Translational Medicine  01 Dec 2010:
Vol. 2, Issue 60, pp. 60ra89
DOI: 10.1126/scitranslmed.3001380

Article Information

vol. 2 no. 60 60ra89

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication June 14, 2010
  • Accepted for publication November 10, 2010
  • .

Author Information

  1. Ashley D. Dierenfeld1,
  2. Michael F. McEntee2,
  3. Carole A. Vogler3,
  4. Charles H. Vite4,
  5. Agnes H. Chen5,
  6. Merry Passage5,
  7. Steven Le5,
  8. Sahil Shah5,
  9. Jackie K. Jens1,
  10. Elizabeth M. Snella1,
  11. Karen L. Kline6,
  12. Jennifer D. Parkes6,
  13. Wendy A. Ware6,
  14. Lori E. Moran6,
  15. Amanda J. Fales-Williams7,
  16. Jane A. Wengert6,
  17. R. David Whitley6,
  18. Daniel M. Betts6,
  19. Amy M. Boal6,
  20. Elizabeth A. Riedesel6,
  21. William Gross6,
  22. N. Matthew Ellinwood1,6,* and
  23. Patricia I. Dickson5
  1. 1Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, IA 50011–3150, USA.
  2. 2Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
  3. 3Department of Pathology, St. Louis University, St. Louis, MO 63104, USA.
  4. 4Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104–6010, USA.
  5. 5Los Angeles Biomedical Research Institute at Harbor–UCLA Medical Center, and the Department of Pediatrics at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
  6. 6Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011–1250, USA.
  7. 7Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011–1250, USA.
  1. *To whom correspondence should be addressed. E-mail: mellinwo{at}iastate.edu

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