01 December 2010
Vol 2, Issue 60

About The Cover

Cover image expansion

ONLINE COVER Guess I’ll Go Eat Worms. Shown are eggs (stained with hematoxylin and eosin) of the nematode Trichuris trichiura in a colon biopsy from a patient with ulcerative colitis. Broadhurst et al. set out to examine whether deliberate ingestion of Trichuris eggs by an individual with ulcerative colitis would skew the immune system away from an inflammatory response, thus alleviating the symptoms of this inflammatory disease. Nematodes did indeed alter the proinflammatory IL-17 environment to a more healing IL-22 response, resulting in disease remission. [CREDIT: K. EVASON/UNIVERSITY OF CALIFORNIA, SAN FRANCISCO]