Contents
Vol 2, Issue 59
Contents
Perspective
- Gaseotransmitters: New Frontiers for Translational Science
Endogenous gaseous mediators offer therapeutic opportunities, as well as unexpected challenges for translational science.
Research Articles
- Adducin- and Ouabain-Related Gene Variants Predict the Antihypertensive Activity of Rostafuroxin, Part 1: Experimental Studies
Rostafuroxin lowers blood pressure in rats and disrupts mutant α-adducin and ouabain–Na,K-ATPase complex interaction with the Src-SH2 domain without affecting the interaction of wild-type α-adducin or Na,K-ATPase in the absence of ouabain.
- Adducin- and Ouabain-Related Gene Variants Predict the Antihypertensive Activity of Rostafuroxin, Part 2: Clinical Studies
Five genetic variants that affect Na,K-ATPase interactions predict the blood pressure response to rostafuroxin but not to losartan and hydrochlorothiazide.
Editors' Choice
- MnSOD, Angiogenesis, and Wounds: Let the Healing Begin!
Endothelial progenitor cells treated with gene transfer for MnSOD gene may be a new therapy for wound healing in diabetes patients.
- When a Clot Buster Doesn't Work So Well
A cytochrome gene variant links a reduced response to a common anticlotting drug to poor clinical outcome in heart disease patients.
- Predicting Recurrent Clostridium difficile Infection
IL-8 genotype predicts Clostridium difficile recurrence.
- Recycling Reagents to Improve Antibody Therapy
Engineering therapeutic antibodies to be recycled for repeated use in the body can extend the effectiveness of these biologics.
