24 November 2010
Vol 2, Issue 59

About The Cover

Cover image expansion

ONLINE COVER Renal Tubules. A cross section from the kidney of a strain of rat with hypertension. Immunofluorescent staining of α-adducin (green) and phosphorylated Src (red) reveals colocalization of these proteins (yellow). Variable interaction of α-adducin and Src with the Na+,K+ ATPase affects how much sodium is recaptured from the urine and, thereby, determines blood pressure. Certain genetic variants predict whether a particular individual will be responsive to an antihypertensive drug targeting these interactions, as described by Ferrandi et al. and Lanzani et al. [CREDIT: G. BIANCHI, UNIVERSITÀ VITA SALUTE SAN RAFFAELE, MILAN, ITALY]