Research ArticleTissue Engineering

Prevention of Muscle Aging by Myofiber-Associated Satellite Cell Transplantation

See allHide authors and affiliations

Science Translational Medicine  10 Nov 2010:
Vol. 2, Issue 57, pp. 57ra83
DOI: 10.1126/scitranslmed.3001081

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Skeletal muscle is dynamic, adapting to environmental needs, continuously maintained, and capable of extensive regeneration. These hallmarks diminish with age, resulting in a loss of muscle mass, reduced regenerative capacity, and decreased functionality. Although the mechanisms responsible for this decline are unclear, complex changes within the local and systemic environment that lead to a reduction in regenerative capacity of skeletal muscle stem cells, termed satellite cells, are believed to be responsible. We demonstrate that engraftment of myofiber-associated satellite cells, coupled with an induced muscle injury, markedly alters the environment of young adult host muscle, eliciting a near-lifelong enhancement in muscle mass, stem cell number, and force generation. The abrogation of age-related atrophy appears to arise from an increased regenerative capacity of the donor stem cells, which expand to occupy both myonuclei in myofibers and the satellite cell niche. Further, these cells have extensive self-renewal capabilities, as demonstrated by serial transplantation. These near-lifelong, physiological changes suggest an approach for the amelioration of muscle atrophy and diminished function that arise with aging through myofiber-associated satellite cell transplantation.


  • * Present address: Departments of Neurology, Medicine, and Biochemistry, University of Washington Medical School, Seattle, WA 98195, USA.

  • Citation: J. K. Hall, G. B. Banks, J. S. Chamberlain, B. B. Olwin, Prevention of Muscle Aging by Myofiber-Associated Satellite Cell Transplantation. Sci. Transl. Med. 2, 57ra83 (2010).

View Full Text

Stay Connected to Science Translational Medicine