27 October 2010
Vol 2, Issue 55

About The Cover

Cover image expansion

ONLINE COVER Going for Gold. A major hurdle to successful breast cancer therapy is the resistance of a small population of cancer stem cells in the tumor to radiation and drug treatment. A research article in this issue (Atkinson et al.) now shows that heating up breast tumor tissue using gold nanoshells activated by laser light sensitizes the cancer stem cells to radiation. After combined heat and radiation treatment, breast cancer stem cells (blue) are less efficient at repairing damaged DNA resulting in an increase in DNA double-strand breaks (green and red dots) and tumor cell death (red). [CREDIT: R. L. ATKINSON, S. PEDDIBHOTLA, J. M. ROSEN/ BAYLOR COLLEGE OF MEDICINE]