Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens

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  Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens

  By Brian Alexander, Jennifer Warner-Schmidt, Therese M. Eriksson, Carol Tamminga, Margarita Arango-Lievano, Subroto Ghose, Mary Vernov, Mihaela Stavarache, Sergei Musatov, Marc Flajolet, Per Svenningsson, Paul Greengard, Michael G. Kaplitt

  Science Translational Medicine20 Oct 2010 : 54ra76

  Reduction of the 5-HT_1B receptor–binding protein p11 in the mouse nucleus accumbens induces depression-like behaviors, and gene therapy to restore p11 expression in this region reverses depression-like behaviors.

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  Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens

  By Brian Alexander, Jennifer Warner-Schmidt, Therese M. Eriksson, Carol Tamminga, Margarita Arango-Lievano, Subroto Ghose, Mary Vernov, Mihaela Stavarache, Sergei Musatov, Marc Flajolet, Per Svenningsson, Paul Greengard, Michael G. Kaplitt

  Science Translational Medicine20 Oct 2010 : 54ra76

  Reduction of the 5-HT_1B receptor–binding protein p11 in the mouse nucleus accumbens induces depression-like behaviors, and gene therapy to restore p11 expression in this region reverses depression-like behaviors.

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