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PTEN Deficiency in Endometrioid Endometrial Adenocarcinomas Predicts Sensitivity to PARP Inhibitors

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Science Translational Medicine  13 Oct 2010:
Vol. 2, Issue 53, pp. 53ra75
DOI: 10.1126/scitranslmed.3001538

Article Information

vol. 2 no. 53 53ra75

DOI: 
https://doi.org/10.1126/scitranslmed.3001538
PubMed: 
20944090
Published By: 
American Association for the Advancement of Science
Print ISSN: 
1946-6234
Online ISSN: 
1946-6242
History: 
  • Received for publication July 29, 2010
  • Accepted for publication September 21, 2010
  • .
Copyright & Usage: 
Copyright © 2010, American Association for the Advancement of Science

Author Information

  1. Konstantin J. Dedes,
  2. Daniel Wetterskog,
  3. Ana M. Mendes-Pereira,
  4. Rachael Natrajan,
  5. Maryou B. Lambros,
  6. Felipe C. Geyer,
  7. Radost Vatcheva,
  8. Kay Savage,
  9. Alan Mackay,
  10. Christopher J. Lord,
  11. Alan Ashworth and
  12. Jorge S. Reis-Filho*
  1. The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, SW3 6JB London, UK.
  1. *To whom correspondence should be addressed. E-mail: jorge.reis-filho{at}icr.ac.uk

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  • PTEN Deficiency in Endometrioid Endometrial Adenocarcinomas Predicts Sensitivity to PARP Inhibitors

    By Konstantin J. Dedes, Daniel Wetterskog, Ana M. Mendes-Pereira, Rachael Natrajan, Maryou B. Lambros, Felipe C. Geyer, Radost Vatcheva, Kay Savage, Alan Mackay, Christopher J. Lord, Alan Ashworth, Jorge S. Reis-Filho

    Science Translational Medicine : 53ra75

    Endometrioid endometrial cancer cell lines harboring PTEN loss of function have impaired homologous recombination response to DNA double-strand breaks and show an exquisite sensitivity to PARP inhibition.

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