Contents
Vol 2, Issue 53
Contents
Commentary
- Strategies for Translational Research in the United Kingdom
The United Kingdom has made a substantial investment in translational research, resulting in a well-developed infrastructure designed to advance clinical medicine.
Perspective
- Network Dynamics to Evaluate Performance of an Academic Institution
Creation of a network of research collaborations allows assessment of a Clinical and Translational Science Award recipient.
Research Articles
- A Defined Tuberculosis Vaccine Candidate Boosts BCG and Protects Against Multidrug-Resistant Mycobacterium tuberculosis
A vaccine with a four-protein fusion peptide from Mycobacterium tuberculosis effectively boosts the current childhood TB vaccine and protects against drug-resistant TB.
- PTEN Deficiency in Endometrioid Endometrial Adenocarcinomas Predicts Sensitivity to PARP Inhibitors
Endometrioid endometrial cancer cell lines harboring PTEN loss of function have impaired homologous recombination response to DNA double-strand breaks and show an exquisite sensitivity to PARP inhibition.
Editors' Choice
- Fatty Eggs and Infertility
Lipotoxicity in ovarian cells may account for the reduced fertility observed in obese women.
- New Cause for Diabetic Nephropathy
The deletion of the insulin receptor only in kidney podocytes induces diabetic nephropathy in mice.
- Mapping Human Disease Risk
A third-generation human HapMap will help to decode the heritable component of human disease risk.
- To Vaccinate or Not: Parents Decide
Although prophylactic human papillomavirus vaccines now are available, fewer than 20% of girls 9 to 26 years of age have completed the three-dose series.
