Research ArticleAutoimmune Disease

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

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Science Translational Medicine  06 Oct 2010:
Vol. 2, Issue 52, pp. 52ra72
DOI: 10.1126/scitranslmed.3001107

Article Information

vol. 2 no. 52 52ra72

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication March 24, 2010
  • Accepted for publication September 10, 2010

Author Information

  1. Wolfgang Hueber1,
  2. Dhavalkumar D. Patel1,*,
  3. Thaddeus Dryja2,
  4. Andrew M. Wright3,
  5. Irina Koroleva2,
  6. Gerard Bruin1,
  7. Christian Antoni4,
  8. Zoe Draelos5,
  9. Michael H. Gold6,
  10. the Psoriasis Study Group,
  11. Patrick Durez7,
  12. Paul P. Tak8,
  13. Juan J. Gomez-Reino9,
  14. the Rheumatoid Arthritis Study Group,
  15. C. Stephen Foster10,
  16. Rosa Y. Kim11,
  17. C. Michael Samson12,
  18. Naomi S. Falk13,
  19. David S. Chu14,
  20. David Callanan15,
  21. Quan Dong Nguyen16,
  22. the Uveitis Study Group,
  23. Kristine Rose4,
  24. Asifa Haider4 and
  25. Franco Di Padova1
  1. 1Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
  2. 2Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
  3. 3Novartis Pharma AG, 4056 Basel, Switzerland.
  4. 4Novartis Pharmaceuticals, East Hanover, NJ 07936, USA.
  5. 5Dermatology Consulting Services, High Point, NC 27265, USA.
  6. 6Tennessee Clinical Research Center, Nashville, TN 37215, USA.
  7. 7Université Catholique de Louvain, 1200 Brussels, Belgium.
  8. 8Academic Medical Center/University of Amsterdam, 1105 AZ Amsterdam, Netherlands.
  9. 9Hospital Clínico Universitario/Universidad de Santiago de Compostela, 15706 Santiago de Compostela, Spain.
  10. 10Massachusetts Eye Research and Surgery Institute, Cambridge, MA 02142, USA.
  11. 11Retina Consultants of Houston, Houston, TX 77030, USA.
  12. 12The New York Eye and Ear Infirmary, New York, NY 10003, USA.
  13. 13Retina Consultants, Slingerlands, New York, NY 12159, USA.
  14. 14Cornea and Laser Eye Institute, Teaneck, NJ 07666, USA.
  15. 15Texas Retina Associates, Arlington, TX 76012, USA.
  16. 16Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  1. *To whom correspondence should be addressed. E-mail: office.patel{at}novartis.com

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