Contents

Contents

• Commentaries

  • Opening Up to Precompetitive Collaboration

    By Jill S. Altshuler, Erin Balogh, Anna D. Barker, Stephen L. Eck, Stephen H. Friend, Geoffrey S. Ginsburg, Roy S. Herbst, Sharyl J. Nass, Christopher M. Streeter, John A. Wagner

    Science Translational Medicine06 Oct 2010 : 52cm26 Full AccessRestricted Access

    The move to increase biomedical R&D efficiency and innovation has stimulated the development of collaborations, among competitors, that span the precompetitive space.

    • Abstract
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  • The Bayh-Dole Act Turns 30

    By Vicki Loise, Ashley J. Stevens

    Science Translational Medicine06 Oct 2010 : 52cm27 Full AccessRestricted Access

    The act that gave U.S. institutions the right to claim title to inventions resulting from federally funded work dramatically increased public benefits from research.

    • Abstract
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• Research Articles

  • Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

    By Wolfgang Hueber, Dhavalkumar D. Patel, Thaddeus Dryja, Andrew M. Wright, Irina Koroleva, Gerard Bruin, Christian Antoni, Zoe Draelos, Michael H. Gold, the Psoriasis Study Group, Patrick Durez, Paul P. Tak, Juan J. Gomez-Reino, the Rheumatoid Arthritis Study Group, C. Stephen Foster, Rosa Y. Kim, C. Michael Samson, Naomi S. Falk, David S. Chu, David Callanan, Quan Dong Nguyen, the Uveitis Study Group, Kristine Rose, Asifa Haider, Franco Di Padova

    Science Translational Medicine06 Oct 2010 : 52ra72 Full AccessRestricted Access

    A human antibody to interleukin-17A is well tolerated and may be effective in the treatment of psoriasis, rheumatoid arthritis, and noninfectious uveitis.

    • Editor's Summary
    • Abstract
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  • PGC-1α, A Potential Therapeutic Target for Early Intervention in Parkinson’s Disease

    By Bin Zheng, Zhixiang Liao, Joseph J. Locascio, Kristen A. Lesniak, Sarah S. Roderick, Marla L. Watt, Aron C. Eklund, Yanli Zhang-James, Peter D. Kim, Michael A. Hauser, Edna Grünblatt, Linda B. Moran, Silvia A. Mandel, Peter Riederer, Renee M. Miller, Howard J. Federoff, Ullrich Wüllner, Spyridon Papapetropoulos, Moussa B. Youdim, Ippolita Cantuti-Castelvetri, Anne B. Young, Jeffery M. Vance, Richard L. Davis, John C. Hedreen, Charles H. Adler, Thomas G. Beach, Manuel B. Graeber, Frank A. Middleton, Jean-Christophe Rochet, Clemens R. Scherzer, the Global PD Gene Expression (GPEX) Consortium

    Science Translational Medicine06 Oct 2010 : 52ra73 Full AccessRestricted Access

    Abnormal expression of genes for energy regulation in Parkinson’s disease patients identifies a master regulator as a possible therapeutic target for early intervention.

    • Editor's Summary
    • Abstract
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• Editors' Choice

  • Turning Off the Cancer Switch

    By Joshi Alumkal

    Science Translational Medicine06 Oct 2010 : 52ec153 Full AccessRestricted Access

    A new drug that blocks BMK1 inhibits tumor growth with minimal toxicity.

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  • PANDERing to the Liver in Glucose Control

    By Rhonda Bentley-Lewis

    Science Translational Medicine06 Oct 2010 : 52ec154 Full AccessRestricted Access

    A new cytokine-like protein produced by the pancreas regulates glucose production in the liver during fasting.

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  • Making Comparative Effectiveness Research Useful

    By Nichole Carlson

    Science Translational Medicine06 Oct 2010 : 52ec155 Full AccessRestricted Access

    The value of comparative effectiveness research depends on applying appropriate design and analysis principles.

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  • Bridging the Gap in Spinal Cord Injury

    By Elaine Cheng

    Science Translational Medicine06 Oct 2010 : 52ec156 Full AccessRestricted Access

    Valproic acid coaxes transplanted neural stem cells to differentiate into neurons that boost repair of spinal cord injury in mice.

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