Research ArticleSepsis

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

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Science Translational Medicine  29 Sep 2010:
Vol. 2, Issue 51, pp. 51ra71
DOI: 10.1126/scitranslmed.3001118

Article Information

vol. 2 no. 51 51ra71

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication March 29, 2010
  • Accepted for publication September 3, 2010
  • .

Author Information

  1. Rasmus Larsen1,
  2. Raffaella Gozzelino1,
  3. Viktória Jeney1,
  4. László Tokaji1,
  5. Fernando A. Bozza2,3,
  6. André M. Japiassú2,3,
  7. Dolores Bonaparte1,
  8. Moisés Marinho Cavalcante1,*,
  9. Ângelo Chora1,
  10. Ana Ferreira1,
  11. Ivo Marguti1,
  12. Sílvia Cardoso1,
  13. Nuno Sepúlveda1,4,
  14. Ann Smith5 and
  15. Miguel P. Soares1,
  1. 1Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal.
  2. 2Intensive Care Unit, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, 21040-900 Rio de Janeiro, Brazil.
  3. 3D’Or Institute for Research and Education, 22281-100 Rio de Janeiro, Brazil.
  4. 4Center of Statistics and Applications of the University of Lisbon, Campo Grande, 1749-016 Lisbon, Portugal.
  5. 5Division of Molecular Biology and Biochemistry, University of Missouri, 5007 Rockhill Road, Kansas City, MO 64110, USA.
  1. To whom correspondence should be addressed. E-mail: mpsoares{at}igc.gulbenkian.pt

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