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Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

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Science Translational Medicine  29 Sep 2010:
Vol. 2, Issue 51, pp. 51ra70
DOI: 10.1126/scitranslmed.3001599

Article Information

vol. 2 no. 51 51ra70

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication March 9, 2010
  • Accepted for publication September 10, 2010
  • .

Author Information

  1. Silvia Buonamici1,*,
  2. Juliet Williams1,*,
  3. Michael Morrissey1,
  4. Anlai Wang1,
  5. Ribo Guo1,
  6. Anthony Vattay1,
  7. Kathy Hsiao1,
  8. Jing Yuan1,
  9. John Green1,
  10. Beatriz Ospina1,
  11. Qunyan Yu1,
  12. Lance Ostrom1,
  13. Paul Fordjour1,
  14. Dustin L. Anderson1,
  15. John E. Monahan1,
  16. Joseph F. Kelleher1,
  17. Stefan Peukert1,
  18. Shifeng Pan2,
  19. Xu Wu2,
  20. Sauveur-Michel Maira3,
  21. Carlos García-Echeverría3,,
  22. Kimberly J. Briggs4,
  23. D. Neil Watkins5,
  24. Yung-mae Yao1,
  25. Christoph Lengauer1,,
  26. Markus Warmuth1,
  27. William R. Sellers1 and
  28. Marion Dorsch1,§
  1. 1Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  2. 2Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
  3. 3Novartis Institutes for Biomedical Research, 4057 Basel, Switzerland.
  4. 4Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA.
  5. 5Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia.
  1. To whom correspondence should be addressed. E-mail: marion.dorsch{at}sanofi-aventis.com

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