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Abstract
As a way of enhancing infections, bacterial pathogens often alter host cell signaling pathways. Here, we describe recent work that highlights a new phosphatase from an intestinal and wound-invading pathogen that manipulates host cell phosphoinositide circuits. Despite the active-site homology between bacterial inositol phosphatases and mammalian phosphatases, sequence differences between them suggest that the development of specific inhibitors may be feasible.
Footnotes
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Citation: R. Lu, M. B. Goldberg, Bacterial exploitation of host cell signaling. Sci. Transl. Med. 2, 51ps48 (2010).
- Copyright © 2010, American Association for the Advancement of Science
