PerspectiveInfectious Disease

Bacterial Exploitation of Host Cell Signaling

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Science Translational Medicine  29 Sep 2010:
Vol. 2, Issue 51, pp. 51ps48
DOI: 10.1126/scitranslmed.3001612

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As a way of enhancing infections, bacterial pathogens often alter host cell signaling pathways. Here, we describe recent work that highlights a new phosphatase from an intestinal and wound-invading pathogen that manipulates host cell phosphoinositide circuits. Despite the active-site homology between bacterial inositol phosphatases and mammalian phosphatases, sequence differences between them suggest that the development of specific inhibitors may be feasible.


  • Citation: R. Lu, M. B. Goldberg, Bacterial exploitation of host cell signaling. Sci. Transl. Med. 2, 51ps48 (2010).

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