29 September 2010
Vol 2, Issue 51
  • Contents

    • Commentary

    • Perspective

    • Research Articles

      • Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

        Resistance of medulloblastoma to Smo antagonists can be delayed or prevented by specific drug combinations.

      • A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

        Heme from red blood cells released in septic shock worsens organ dysfunction and increases the risk of death, but can be overcome by a scavenger of free heme.

    • Editors' Choice

      • GPR120 Mediates the Benefits of Fish Oil

        GPR120, an ω-3 fatty acid sensor expressed in macrophages and fat cells, exerts anti-inflammatory and insulin-like effects.

      • Rewiring the Brain After Stroke

        A new study finds altered communication between the brain’s hemispheres after stroke.

      • When the Guardian Looks Away

        The same single-nucleotide polymorphism in the p53 regulator MDM2 increases cancer risk in mice but is a marker of less aggressive prostate cancer in humans.

About The Cover

Cover image expansion

ONLINE COVER Mouse Myocardium, with a Coronary Vessel. During sepsis, damaged red blood cells leak heme, which is toxic to numerous organs, including the heart, where it causes myocardial necrosis, as discussed in this week's Research Article by Larsen et al. The enzyme heme oxygenase can counteract these effects of heme, protecting mice from sepsis-induced death. [CREDIT: RASMUS LARSEN ET AL., INSTITUTO GULBENKIAN DE CIENCIA, PORTUGAL]