Contents
Vol 2, Issue 50
Contents
Research Article
- A Naturally Occurring Human Minidysferlin Protein Repairs Sarcolemmal Lesions in a Mouse Model of Dysferlinopathy
A naturally occurring miniversion of the dysferlin protein found in a patient shows that gene therapy by minigene transfer may be possible in dysferlinopathies.
Review
- Long Synthetic Peptides for the Production of Vaccines and Drugs: A Technological Platform Coming of Age
Improved methods for producing long synthetic peptides, together with bioinformatics approaches, offer promise for the development of clinically relevant products.
Editors' Choice
- PPARγ and the Placenta: Lessons That Could Inform Cancer Therapy
Peroxisome proliferator–activated receptor γ plays a role in placental angiogenesis, a finding with possible relevance for the treatment of metastatic cancer.
- Beating Heart Disease in Diabetes
An apoA-I mimetic that prevents fatty lesion formation in diabetic mice may prevent premature heart disease in patients with diabetes.
- Antiplatelet Therapy: To Genotype or Not?
A recent study does not overturn the conclusion that DNA sequence polymorphisms in the hepatic cytochrome 2C19 gene are predictive of future adverse cardiovascular events.
- Breath of Fresh Air: Tissue-Engineered Tracheas for Airway Repair
Tissue-engineered tracheas move one step closer as a clinical treatment.
Letters
- Comment on "The Origins of Sexually Transmitted HIV Among Men Who Have Sex with Men"
Unexpected diversity of HIV strains in infected patients reported by Butler et al. indicates that there are problems with the validity of the analysis and, therefore, the conclusion that seminal plasma is the main source of infecting virus.
- Response to Comment on "The Origins of Sexually Transmitted HIV Among Men Who Have Sex with Men"
The excessive viral diversity noted by Heath et al. in our sample of infected HIV patients prompted us to reexamine our data. Doing so uncovered several mislabeled samples, but no sources of contamination were identified. Investigations into additional transmission pairs will be needed to further investigate these issues.
Erratum
