22 September 2010
Vol 2, Issue 50

About The Cover

Cover image expansion

ONLINE COVER Muscles with a Minigene. Multiplied images of muscle cross-sections from a patient with mild muscle weakness. In this week's issue of Science Translational Medicine by Krahn et al., staining with NADH dehydrogenase reveals a dystrophic pattern, a result of deletion of exons 2 to 40 of the dysferlin gene, which is essential for membrane repair. This deletion creates a truncated dyferlin protein in this patient that confers partial function and may be useful for gene therapy of these muscle-wasting dysferlinopathies. [CREDIT: N. STREICHENBERGER/HOPITAL NEUROLOGIQUE, LYON]