15 September 2010
Vol 2, Issue 49
  • Contents

    • Commentary

      • A Multi-Level Systems Perspective for the Science of Team Science

        Understanding how teams function is vital because they are increasingly dominating the production of high-impact science.

    • Perspective

      • GIP: No Longer the Neglected Incretin Twin?

        A pair of complementary studies suggest that scientists consider the incretin hormone gastric inhibitory polypeptide as a new therapeutic target for Type 2 diabetes.

    • Research Articles

      • Personalized Epigenomic Signatures That Are Stable Over Time and Covary with Body Mass Index

        A genome-scale, gene-specific analysis of DNA methylation in the same individuals over a decade apart identifies a personalized epigenomic signature that may correlate with a common genetic trait.

      • Disruption at the PTCHD1 Locus on Xp22.11 in Autism Spectrum Disorder and Intellectual Disability

        Mutations of the X-linked gene PTCHD1 are associated with autism spectrum disorders and intellectual disability.

    • Editors' Choice

      • A New “Fix” for Cancer

        Overexpression of an oncogenic microRNA leads to pre–B cell lymphoma.

      • Next-Generation Sequencing: A Better Way

        The cost of next-generation sequencing can be lowered, without loss of power, by pooling samples from more subjects and sequencing at a lower depth.

      • Molecular Snapshot

        A new microfluidic device allows for easy isolation of neutrophils for genomic and proteomic analyses.

About The Cover

Cover image expansion

ONLINE COVER Mouse Embryo Showing mRNA for the Autism-Associated Gene PTCHD1. Various deletions and missense mutations in and around the gene PTCHD1 contribute to the abnormal brain function of people with autism spectrum disorder. Examination of expression pattern of the gene, as in this mouse embryo, can help to explain how its altered state contributes to this disorder, as discussed by Noor et al. [CREDIT: RONG MO/THE HOSPITAL FOR SICK CHILDREN, TORONTO]