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Abstract
In this issue of Science Translational Medicine, Wallin et al. have identified a subset of breast and ovarian cancer cell lines that show synergistic response to the combination of doxorubicin and GDC-0941, a class IA phosphatidylinositol 3-kinase (PI3K) inhibitor. Here, we discuss the potential implications of these data on the clinical development of PI3K pathway inhibitors as cancer therapeutics.
Footnotes
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Citation: A. P. Myers, L. C. Cantley, Targeting a common collaborator in cancer development. Sci. Transl. Med. 2, 48ps45 (2010).
- Copyright © 2010, American Association for the Advancement of Science
