Contents
Vol 2, Issue 47
Contents
Perspectives
- Molecular Profiling: Moving Away from Tumor Philately
Cutting-edge technologies that deliver diverse molecular data may dramatically alter breast cancer characterization and treatment.
- Translational Medicine and the Value of Biomarker Qualification
The U.S. Food and Drug Administration's new process for biomarker qualification developed from a need for better biomarkers of renal injury.
Research Articles
- Platelet CD154 Potentiates Interferon-α Secretion by Plasmacytoid Dendritic Cells in Systemic Lupus Erythematosus
In the autoimmune disease lupus, platelets activated by self-antigens contribute to pathology by triggering the secretion of interferon from immune cells.
- Overlap and Effective Size of the Human CD8+ T Cell Receptor Repertoire
Deep sequencing of the T cell receptor repertoires of seven healthy adults reveals that the adaptive immune system is far less diverse than expected and the person-to-person overlap is thousands of times larger.
Editors' Choice
- Immune Regulators: Not Just for Type 1 Diabetes Anymore?
Stimulation of 4-1BB with an agonistic antibody reduces adiposity and body weight, modulates inflammatory cytokine levels, improves glucose/lipid metabolism, and increases energy expenditure, suggesting a role for 4-1BB in the management of obesity and metabolic disorders.
- SORTing Out Lipids
A gene encoding a protein that helps to sort and clear cellular proteins is the most common genetic contributor to plasma LDL concentrations.
- Spy vs. Spy: Recruiting Stem Cells to the War on Cancer
Mesenchymal stem cells can home in and deliver drug-carrying nanoparticles to brain tumors.
