Contents
Vol 2, Issue 44
Contents
Commentary
- Pharmacy Benefit Managers, Pharmacies, and Pharmacogenomic Testing: Prescription for Progress?
As prescription drug costs rise, companies such as Medco are moving to promote pharmacogenomics-based testing to inform therapeutic choices.
Perspective
- Coupled for Cross-Presentation in Tumor Immunotherapy
Bacterial infection–induced gap junctions in melanoma cells shuttle tumor antigens to immune cells and spur a successful antitumor immune response.
Research Articles
- Bacteria-Induced Gap Junctions in Tumors Favor Antigen Cross-Presentation and Antitumor Immunity
Bacterial infection induces extra gap junctions in tumors, through which tumor antigens travel to antigen-presenting cells, triggering an effective antitumor immune response.
- Fatty Acid Oxidation and Malonyl-CoA Decarboxylase in the Vascular Remodeling of Pulmonary Hypertension
The overgrowth of vascular cells that causes pulmonary hypertension can be prevented in mice by inhibiting a metabolic shift toward glycolysis.
Editors' Choice
- Making Research Reproducible
Reproducible research requires that the “hows” and “whys” of statistical methods be made widely available.
- Genomic and Stem-Cell Technologies Collide
Pluripotent stem cells are used to model Long-QT syndromes and explain the functional effects of a prominent mutation in the KCNQ1 gene.
- Rebuilding Broken Bones with Bioactive Ceramics
Novel bioactive ceramics may allow orthopedic trauma surgeons to better repair shattered bones.
