11 August 2010
Vol 2, Issue 44

About The Cover

Cover image expansion

ONLINE COVER Pulmonary Perfusion. Lung arterial vessels, as shown here in a tiny barium angiogram from a rat, become constricted and clogged in the deadly disease pulmonary hypertension. The extra strain this puts on the heart, as it tries to compensate by pumping harder, can ultimately lead to heart failure. Overgrowth of the cells lining the vessel walls causes the constriction, and an article by Sutendra et al. reports that these overactive cells share metabolic features with cancer cells. [CREDIT: G. SUTENDRA]