04 August 2010
Vol 2, Issue 43

About The Cover

Cover image expansion

ONLINE COVER A Gene-Environment Collaboration. The abnormal gut section modeled here reveals changes that may be associated with virus-triggered colitis, an inflammation of the gut. In this week's Perspective, Peterson and Turnbaugh discuss a recent report that examines how studies that focus on genetic polymorphisms identified in genome-wide association studies—in this case, a mutation identified as a risk factor for the inflammatory gut condition Crohn's disease—can provide insight into the environmental factors that drive disease pathogenesis. The findings prompt new hypotheses that relate inflammation, host immune status, microbial community structure, and human health. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]