Research ArticleCancer Immunology

CD4+CD25+ Regulatory T Cell Depletion Improves the Graft-Versus-Tumor Effect of Donor Lymphocytes After Allogeneic Hematopoietic Stem Cell Transplantation

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Science Translational Medicine  21 Jul 2010:
Vol. 2, Issue 41, pp. 41ra52
DOI: 10.1126/scitranslmed.3001302

Article Information

vol. 2 no. 41 41ra52

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication May 20, 2010
  • Accepted for publication July 2, 2010
  • .

Author Information

  1. Sébastien Maury1,2,*,
  2. François M. Lemoine3,4,
  3. Yosr Hicheri1,2,,
  4. Michelle Rosenzwajg3,4,,
  5. Cécile Badoual5,6,
  6. Mustapha Cheraï3,4,
  7. Jean-Louis Beaumont7,
  8. Nabih Azar3,
  9. Nathalie Dhedin8,
  10. Anne Sirvent9,
  11. Agnès Buzyn10,
  12. Marie-Thérèse Rubio10,
  13. Stéphane Vigouroux11,
  14. Olivier Montagne2,12,
  15. Dominique Bories1,2,
  16. Françoise Roudot-Thoraval2,13,
  17. Jean-Paul Vernant8,
  18. Catherine Cordonnier1,2,
  19. David Klatzmann3,4, and
  20. José L. Cohen4,8,*
  1. 1Department of Hematology, Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, Créteil F-94010, France.
  2. 2Université Paris-Est Créteil Val de Marne, Créteil F-94010, France.
  3. 3Department of Biotherapies, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Paris F-75013, France.
  4. 4Centre National de la Recherche Scientifique UMR 7211, Université Pierre et Marie Curie Paris 06, Paris F-75013, France.
  5. 5Department of Pathology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris F-75015, France.
  6. 6Ecole Nationale Vétérinaire d’Alfort, EA4054, Paris Descartes University, Paris F-75005, France.
  7. 7Department of Hemapheresis, Etablissement Français du Sang d’Ile de France, Créteil F-94010, France.
  8. 8Department of Hematology, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Paris F-75013, France.
  9. 9Department of Hematology, Hôpital Archet, Nice F-06000, France.
  10. 10Department of Hematology, Hôpital Necker, Paris F-75015, France.
  11. 11Department of Hematology, Hôpital Haut-Leveque, Bordeaux F-33000, France.
  12. 12Center for Clinical Investigation in Biotherapy, Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, Créteil F-94010, France.
  13. 13Department of Public Health, Assistance Publique-Hôpitaux de Paris, Hôpital Henri Mondor, Créteil F-94010, France.
  1. *To whom correspondence should be addressed. E-mail: sebastien.maury{at}hmn.aphp.fr (S.M.); jose.cohen{at}upmc.fr (J.L.C.)

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