PerspectiveHigh-Performance Computing

Closing the Scientific Loop: Bridging Correlation and Causality in the Petaflop Age

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Science Translational Medicine  21 Jul 2010:
Vol. 2, Issue 41, pp. 41ps34
DOI: 10.1126/scitranslmed.3000390

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Advances in computing capability offer the biomedical research community the prospect of creating simulations at a previously unimaginable scale. A diagnostic analysis of the underpinnings of the translational dilemma suggests that the current high-throughput, data-rich research environment has led to an imbalance in the relationship between determinations of correlation and the evaluation of causality. Here I describe the use of high-performance computing technologies to facilitate high-throughput hypothesis evaluation combined with an evolutionary paradigm for the advancement of scientific knowledge. This combination provides a roadmap for closing the scientific loop between correlation and causality, a necessary step if translational endeavors are to succeed.


  • Citation: G. An, Closing the scientific loop: Bridging correlation and causality in the petaflop age. Sci. Transl. Med. 2, 41ps34 (2010).

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