21 July 2010
Vol 2, Issue 41
  • Contents

    • Perspectives

    • Research Articles

    • Editors' Choice

      • Decoding Sudden Cardiac Death

        A genome association study has identified a genetic variant that is present in over half of individuals with ventricular fibrillation and confers a large increase in risk for this arrhythmia.

      • Adapting to Aging and Metabolism

        Targeted disruption of the adaptor protein p66shcA improves longevity and ameliorates obesity-induced insulin resistance.

      • Don’t Worry, Be Happy

        The severity of osteoarthritis pain is associated with depression and mental health.

About The Cover

Cover image expansion

ONLINE COVER . Supercomputers Computers, Superb Simulations. In this week's Perspective, An et al. argues that the current high-throughput, data-rich research environment has led to an imbalance in the relationship between determinations of correlation and the evaluation of causality. As a remedy, the author reminds us that recent advances in computing capabilities offer the biomedical research community the prospect of creating simulations at a previously unimaginable scale. The conclusion: Meeting of the translational challenge presented by complex diseases and datasets requires the use of computer-augmented, high-throughput hypothesis evaluation within an evolutionary paradigm for the propagation of biomedical knowledge. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE; JUPITERIMAGES]